Medical Physics Department, Medical School, University of Athens, 75 Mikras Asias, 11527, Athens, Greece.
Pediatr Radiol. 2013 Mar;43(3):339-46. doi: 10.1007/s00247-012-2510-3. Epub 2012 Oct 24.
Children diagnosed with congenital heart disease often undergo cardiac catheterization for their treatment, which involves the use of ionizing radiation and therefore a risk of radiation-induced cancer.
The purpose of this study was to calculate the effective and equivalent organ doses (H(T)) in those children and estimate the risk of exposure-induced death.
Fifty-three children were divided into three groups: atrial septal defect (ASD), ventricular septal defect (VSD) and patent ductus arteriosus (PDA). In all procedures, the exposure conditions and the dose-area product meters readings were recorded for each individual acquisition. Monte Carlo simulations were run using the PCXMC 2.0 code and mathematical phantoms simulating a child's anatomy. The H(T) values to all irradiated organs and the resulting E and risk of exposure-induced death values were calculated.
The average dose-area product values were, respectively, 40 ± 12 Gy·cm(2) for the ASD, 17.5 ± 0.7 Gy·cm(2) for the VSD and 9.5 ± 1 Gy·cm(2) for the PDA group. The average E values were 40 ± 12, 22 ± 2.5 and 17 ± 3.6 mSv for ASD, VSD and PDA groups, respectively. The respective estimated risk of exposure-induced death values per procedure were 0.109, 0.106 and 0.067%.
Cardiac catheterizations in children involve a considerable risk for radiation-induced cancer that has to be further reduced.
患有先天性心脏病的儿童在治疗过程中经常需要接受心脏导管插入术，该治疗过程涉及使用电离辐射，因此存在辐射致癌的风险。
本研究旨在计算这些儿童的有效和等效器官剂量（H(T)），并估算暴露所致死亡的风险。
将 53 名儿童分为三组：房间隔缺损（ASD）、室间隔缺损（VSD）和动脉导管未闭（PDA）。在所有操作中，记录了每个个体采集的曝光条件和剂量面积乘积计读数。使用 PCXMC 2.0 代码和模拟儿童解剖结构的数学体模进行了蒙特卡罗模拟。计算了所有受照射器官的 H(T)值以及相应的 E 值和暴露所致死亡的风险值。
ASD、VSD 和 PDA 组的平均剂量面积乘积值分别为 40±12 Gy·cm(2)、17.5±0.7 Gy·cm(2)和 9.5±1 Gy·cm(2)。 ASD、VSD 和 PDA 组的平均 E 值分别为 40±12、22±2.5 和 17±3.6 mSv。每个操作程序的估计暴露所致死亡风险值分别为 0.109、0.106 和 0.067%。
儿童心脏导管插入术涉及相当大的辐射致癌风险，需要进一步降低。
