Department of Cell and Molecular Biology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, Uppsala, Sweden.
RNA Biol. 2012 Dec;9(12):1513-9. doi: 10.4161/rna.22578. Epub 2012 Oct 23.
Chromosomally encoded toxin-antitoxin (TA) systems are abundantly present in bacteria and archaea. They have become a hot topic in recent years, because-after many frustrating years of searching for biological functions-some are now known to play roles in persister formation. Persister cells represent a subset of a bacterial population that enters a dormant state and thus becomes refractory to the action of antibiotics. TA modules come in several different flavors, regarding the nature of their gene products, their molecular mechanisms of regulation, their cellular targets, and probably their role in physiology. This review will primarily focus on the SOS-associated tisB/istR1 system in Escherichia coli and discuss its nuts and bolts as well as its effect in promoting a subpopulation phenotype that likely benefits long-term survival of a stressed population.
染色体编码的毒素-抗毒素 (TA) 系统在细菌和古菌中大量存在。近年来，它们已成为一个热门话题，因为——经过多年寻找生物功能的令人沮丧的尝试——现在已知其中一些在持久生物形成中发挥作用。持久生物细胞是细菌种群的一个子集，它们进入休眠状态，因此对抗生素的作用产生抗药性。TA 模块有几种不同的形式，涉及它们的基因产物的性质、它们的调控分子机制、它们的细胞靶标，以及它们在生理学中的作用。这篇综述将主要集中在大肠杆菌中的 SOS 相关 tisB/istR1 系统上，并讨论其结构和功能，以及其促进有利于压力种群长期生存的亚群表型的作用。
