Martens H J, De Goede P N, Van Loenen A C
Department of Pharmacy, Free University Hospital, Amsterdam, The Netherlands.
Am J Hosp Pharm. 1990 Feb;47(2):369-73.
The sorption of chloroquine sulfate, diazepam, isosorbide dinitrate, lorazepam, midazolam, nitroglycerin, promethazine hydrochloride, thiopental sodium, and warfarin sodium to three types of containers was studied. Appropriate amounts of the drugs were added to 500 mL of 0.9% sodium chloride injection in polyvinyl chloride (PVC) bags, glass bottles, and Clear-Flex bags composed of a laminate of polyethylene, nylon, and polypropylene. The containers were stored in the dark at room temperature for 24 hours. Samples were taken at various intervals and assayed for drug concentration by high-performance liquid chromatography. There were no appreciable changes in pH after 24 hours, and all the admixtures remained clear and colorless. The potency of chloroquine sulfate, lorazepam, midazolam, promethazine hydrochloride, and thiopental sodium remained unchanged in glass, PVC, and Clear-Flex containers. Diazepam, isosorbide dinitrate, nitroglycerin, and warfarin sodium did not show any sorption to glass bottles and Clear-Flex bags. In PVC bags, however, up to 55% of diazepam, 23% of isosorbide dinitrate, 51% of nitroglycerin, and 24% of warfarin sodium was lost during the 24-hour study period. Diazepam, isosorbide dinitrate, nitroglycerin, and warfarin sodium in 0.9% sodium chloride injection showed a loss of potency when stored in PVC containers for 24 hours at room temperature, but none of the drugs studied lost potency when stored in glass bottles and Clear-Flex bags.
研究了硫酸氯喹、地西泮、硝酸异山梨酯、劳拉西泮、咪达唑仑、硝酸甘油、盐酸异丙嗪、硫喷妥钠和华法林钠在三种类型容器中的吸附情况。将适量药物加入到500 mL聚氯乙烯（PVC）袋、玻璃瓶和由聚乙烯、尼龙和聚丙烯层压而成的Clear-Flex袋中的0.9%氯化钠注射液中。将容器在室温黑暗处储存24小时。在不同时间间隔取样，通过高效液相色谱法测定药物浓度。24小时后pH值没有明显变化，所有混合液仍保持澄清无色。硫酸氯喹、劳拉西泮、咪达唑仑、盐酸异丙嗪和硫喷妥钠在玻璃、PVC和Clear-Flex容器中的效价保持不变。地西泮、硝酸异山梨酯、硝酸甘油和华法林钠在玻璃瓶和Clear-Flex袋中未显示出任何吸附。然而，在PVC袋中，在24小时的研究期间，高达55%的地西泮、23%的硝酸异山梨酯、51%的硝酸甘油和24%的华法林钠损失了。0.9%氯化钠注射液中的地西泮、硝酸异山梨酯、硝酸甘油和华法林钠在室温下于PVC容器中储存24小时后效价降低，但所研究的药物在玻璃瓶和Clear-Flex袋中储存时均未降低效价。
