Morita M, Iida T, Tsuchiya Y, Aoyama Y
Jikken Dobutsu. 1979 Oct;28(4):537-50. doi: 10.1538/expanim1978.28.4_537.
Fatal herpesvirus tamarinus infection was observed in cotton-topped marmosets (Saguinus oedipus) imported from South America via the United States on August 26, 1976. In addition to the lesions hitherto reported in herpesvirus tamarinus infection, severe degenerative and necrotic changes of ganglion cells were recognized with intranuclear inclusion bodies in the plexus of the digestive tract and the sympathetic nerves and their ganglions in the abdominal cavity. Inflammatory or regressive changes were also noted in the central nervous system. A large number of basophilic or eosinophilic intranuclear inclusion bodies frequently recognized in multinucleated giant cells were observed in various organs and tissues, and they showed different shapes at the electron microscopic level. Morphological findings indicated that herpesvirus tamarinus infection seemed to be similar to herpes simplex virus infection in man. The findings of the susceptibility of a variety of cell cultures to the virus isolate serologically identified as herpesvirus tamarinus and physicochemical characteristics of the virus isolate were in general agreement with the findings of herpesvirus tamarinus already reported by previous workers.
1976年8月26日，在经由美国从南美洲进口的棉顶狨猴（Saguinus oedipus）中观察到了致命的狨猴疱疹病毒感染。除了迄今报道的狨猴疱疹病毒感染的病变外，在消化道神经丛以及腹腔内的交感神经及其神经节中，还发现神经节细胞有严重的变性和坏死变化，并伴有核内包涵体。中枢神经系统也出现了炎症或退行性变化。在各种器官和组织中观察到大量在多核巨细胞中常见的嗜碱性或嗜酸性核内包涵体，并且在电子显微镜下它们呈现出不同的形状。形态学结果表明，狨猴疱疹病毒感染似乎与人单纯疱疹病毒感染相似。各种细胞培养物对血清学鉴定为狨猴疱疹病毒的病毒分离株的敏感性以及该病毒分离株的理化特性的研究结果，与先前研究人员已报道的狨猴疱疹病毒的研究结果总体一致。
