Yoshikawa Y, Ignjatovic J, Bauer H
Differentiation. 1979;15(1):41-7. doi: 10.1111/j.1432-0436.1979.tb01032.x.
It has become evident from recent literature that especially in tumor virus systems, cell transformation leads to an arrest of differentiation or to a retrodifferentiation. This may be reflected by the expression of embryonic antigens and it is therefore particularly important to characterize such antigens according to their specificity as well as to their specificity during embryogenesis. We have demonstrated the expression of embryonic antigens which are cross-reactive in avian fibroblasts transformed either by Rous sarcoma virus or by methylcholanthrene. This paper is intended to demonstrate that these embryonic antigens are detected only at a certain period of embryogenesis and particularly in muscle cells. They are detected only occasionally or not at all in cells of other tissues such as brain, liver, lung, and the digestive organs. These antigens are absent from the target cells before transformation and are consequently induced by the transforming agent, either viral or chemical. Therefore, these results suggest that by transformation mechanism, cells become specifically reverted to an earlier stage of differentiation (retrodifferentiation).
从最近的文献中可以明显看出，特别是在肿瘤病毒系统中，细胞转化会导致分化停滞或逆向分化。这可能通过胚胎抗原的表达得以体现，因此，根据这些抗原在胚胎发生过程中的特异性及其特异性来对其进行表征尤为重要。我们已经证明了在由劳斯肉瘤病毒或甲基胆蒽转化的禽类成纤维细胞中具有交叉反应性的胚胎抗原的表达。本文旨在证明这些胚胎抗原仅在胚胎发生的特定时期被检测到，特别是在肌肉细胞中。在其他组织如脑、肝、肺和消化器官的细胞中，它们只是偶尔被检测到或根本检测不到。这些抗原在转化前的靶细胞中不存在，因此是由转化因子（病毒或化学物质）诱导产生的。所以，这些结果表明，通过转化机制，细胞会特异性地逆转为分化的早期阶段（逆向分化）。
