School of Basic Medicine, Peking Union Medical College & Institute of Basic Medical Science, Chinese Academy of Medical Sciences, Beijing, China.
J Pharmacol Sci. 2012;120(3):139-45. doi: 10.1254/jphs.12r06cp. Epub 2012 Oct 26.
The effects of a single compound and a mixture of traditional Chinese medicine (TCM) on promoting proliferation, differentiation, and migration of neural stem cells and regulating their microenvironment have been observed by Chinese scholars in recent years. These results showed good prospects in improving neural regeneration and repair of neurological disorders such as ischemic brain injury, Alzheimer's disease, Parkinson's disease, and depression. According to the TCM theory, the relationship between life of an individual and the disease was regarded as an entirety, and the theory emphasized the treatment based on syndrome differentiation since ancient times. In this paper, we attempted to introduce these medicines, which belong to natural products and have already been proved to possess clear therapeutic action on human bodies in the clinical setting. We summarized their effects promoting brain neurogenesis and repairing brain injuries in animal models and some mechanisms at the cellular and molecular levels.
近年来，中国学者观察到一种单一化合物和中药（TCM）混合物对促进神经干细胞的增殖、分化和迁移以及调节其微环境的影响。这些结果在改善缺血性脑损伤、阿尔茨海默病、帕金森病和抑郁症等神经障碍的神经再生和修复方面显示出良好的前景。根据中医理论，个体的生命与疾病的关系被视为一个整体，该理论自古以来就强调基于辨证论治的治疗方法。在本文中，我们试图介绍这些药物，它们属于天然产物，在临床实践中已被证明对人体具有明确的治疗作用。我们总结了它们在动物模型中促进脑神经发生和修复脑损伤的作用及其在细胞和分子水平上的一些机制。
