Chen Yu-Qing, Zhang Yan-Xian, Zhang Xu, Lyu Yong-Mei, Miao Zeng-Li, Liu Xiao-Yu, Duan Xu-Chu
School of Life Science, Nantong Laboratory of Development and Diseases, Affiliated Hospital of Nantong University, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, 226019, China.
Department of Pharmacy, Department of Endocrine, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, 226006, China.
Chin J Integr Med. 2025 Mar;31(3):270-280. doi: 10.1007/s11655-024-4004-1. Epub 2024 Dec 2.
Peripheral nerve injury (PNI) encompasses damage to nerves located outside the central nervous system, adversely affecting both motor and sensory functions. Although peripheral nerves possess an intrinsic capacity for self-repair, severe injuries frequently result in significant tissue loss and erroneous axonal junctions, thereby impeding complete recovery and potentially causing neuropathic pain. Various therapeutic strategies, including surgical interventions, biomaterials, and pharmacological agents, have been developed to enhance nerve repair processes. While preclinical studies in animal models have demonstrated the efficacy of certain pharmacological agents in promoting nerve regeneration and mitigating inflammation, only a limited number of these agents have been translated into clinical practice to expedite nerve regeneration. Chinese herb medicine (CHM) possesses a longstanding history in the treatment of various ailments and demonstrates potential efficacy in addressing PNI through its distinctive, cost-effective, and multifaceted methodologies. This review critically examines the advancements in the application of CHM for PNI treatment and nerve regeneration. In particular, we have summarized the most commonly employed and rigorously investigated CHM prescriptions, individual herbs, and natural products, elucidating their respective functions and underlying mechanisms in the context of PNI treatment. Furthermore, we have deliberated on the prospective development of CHM in both clinical practice and fundamental research.
周围神经损伤（PNI）包括中枢神经系统以外神经的损伤，对运动和感觉功能均产生不利影响。尽管周围神经具有自我修复的内在能力，但严重损伤常导致大量组织损失和错误的轴突连接，从而阻碍完全恢复，并可能导致神经性疼痛。为了促进神经修复过程，人们已经开发了多种治疗策略，包括手术干预、生物材料和药物制剂。虽然在动物模型中的临床前研究已经证明某些药物制剂在促进神经再生和减轻炎症方面的有效性，但只有少数这些药物已转化为临床实践以加速神经再生。中药（CHM）在治疗各种疾病方面有着悠久的历史，并通过其独特、经济高效且多方面的方法在解决周围神经损伤方面显示出潜在疗效。本综述批判性地审视了中药在周围神经损伤治疗和神经再生应用方面的进展。特别是，我们总结了最常用且经过严格研究的中药方剂、单味草药和天然产物，阐明了它们在周围神经损伤治疗背景下各自的功能和潜在机制。此外，我们还探讨了中药在临床实践和基础研究中的未来发展。
