Greene-Schloesser Dana, Schnegg Caroline I, Robbins Mike E
Departments of Radiation Oncology and Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Methods Mol Biol. 2013;952:325-36. doi: 10.1007/978-1-62703-155-4_24.
The use of behavioral testing has become an invaluable tool for assessing the efficacy of therapeutics for a variety of disorders of the central nervous system. This chapter will describe in detail several behavioral paradigms to evaluate the efficacy of PPAR agonists to modulate cognitive impairments in rodent models. When used together as a battery these procedures allow for a global assessment of cognition. These tests are explained in detail below, and include: (1) Novel Object Recognition (NOR), (2) Morris Water Maze (MWM), (3) Delay Match to Place (DMP), and (4) Cue Strategy.
行为测试的应用已成为评估针对各种中枢神经系统疾病的治疗药物疗效的宝贵工具。本章将详细描述几种行为范式，以评估过氧化物酶体增殖物激活受体（PPAR）激动剂在啮齿动物模型中调节认知障碍的疗效。当作为一组测试一起使用时，这些程序可对认知进行全面评估。以下将详细解释这些测试，包括：（1）新物体识别测试（NOR），（2）莫里斯水迷宫实验（MWM），（3）延迟位置匹配任务（DMP），以及（4）线索策略。
