Singi Shailesh R, Fernandez Evita, Pandya Sunil T, Badrinath H R
CARE Hospitals, Banjara Hills, Hyderabad, 500 082 AP India.
Indian J Hematol Blood Transfus. 2009 Mar;25(1):1-5. doi: 10.1007/s12288-009-0001-y. Epub 2009 Apr 6.
Postpartum hemorrhage is leading cause of maternal mortality and still remains a challenging condition to treat and hysterectomy may be required to control the bleeding once medical interventions fail. These strategies are not always successful and a direct approach in activating the coagulation system can be more effective and life saving. We describe here the mechanism of action of rFVIIa, review of literature and its use in 10 cases with different causes for PPH with good response.
产后出血是孕产妇死亡的主要原因，并且仍然是一种难以治疗的情况，一旦医学干预失败，可能需要进行子宫切除术来控制出血。这些策略并不总是成功的，直接激活凝血系统的方法可能更有效且能挽救生命。我们在此描述重组活化凝血因子VII（rFVIIa）的作用机制、文献综述及其在10例不同原因产后出血且反应良好的病例中的应用。
