Samanta Dipti R, Senapati Surendra N, Sharma Praveen K, Shruthi B S, Paty Prajna Bimoch, Sarangi Gitanjali
A. H. Regional Cancer Centre, Cuttack, Orissa India.
Indian J Hematol Blood Transfus. 2009 Mar;25(1):36-9. doi: 10.1007/s12288-009-0009-3. Epub 2009 Apr 6.
Palatal perforation can occur due to trauma, infection and malignancy. Mucormycosis is a rare opportunistic fungal infection caused by an organism of class zygomycetes. Rhinocerebral mucormycosis is the most common type of mucormycosis that typically starts in maxillary antrum in immunocompromised patients. Invasion of surrounding structures leads to necrotizing ulcer of the hard palate and ultimately leads to perforation. Here, we report a case of perforation of the hard palate due to mucormycosis in a eight years child having acute lymphoblastic leukemia (ALL), who was on prolonged chemotherapy and corticosteroid therapy. This case is being reported for its rarity. The aim of presenting this case report is to emphasize that the infection due to mucomycosis should be included in the differential diagnosis of hard palate perforation in ALL patients who are immunocompromised.
腭部穿孔可因外伤、感染和恶性肿瘤引起。毛霉菌病是一种由接合菌纲生物引起的罕见机会性真菌感染。鼻脑型毛霉菌病是最常见的毛霉菌病类型,通常始于免疫功能低下患者的上颌窦。周围结构的侵犯导致硬腭坏死性溃疡,最终导致穿孔。在此,我们报告一例8岁急性淋巴细胞白血病(ALL)患儿因毛霉菌病导致硬腭穿孔的病例,该患儿正在接受长期化疗和皮质类固醇治疗。该病例因其罕见性而被报道。本病例报告的目的是强调在免疫功能低下的ALL患者中,毛霉菌病感染应纳入硬腭穿孔的鉴别诊断。