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毛霉菌病致急性淋巴细胞白血病硬腭穿孔——1例报告

Hard palate perforation in acute lymphoblastic leukemia due to mucormycosis - a case report.

作者信息

Samanta Dipti R, Senapati Surendra N, Sharma Praveen K, Shruthi B S, Paty Prajna Bimoch, Sarangi Gitanjali

机构信息

A. H. Regional Cancer Centre, Cuttack, Orissa India.

出版信息

Indian J Hematol Blood Transfus. 2009 Mar;25(1):36-9. doi: 10.1007/s12288-009-0009-3. Epub 2009 Apr 6.

Abstract

Palatal perforation can occur due to trauma, infection and malignancy. Mucormycosis is a rare opportunistic fungal infection caused by an organism of class zygomycetes. Rhinocerebral mucormycosis is the most common type of mucormycosis that typically starts in maxillary antrum in immunocompromised patients. Invasion of surrounding structures leads to necrotizing ulcer of the hard palate and ultimately leads to perforation. Here, we report a case of perforation of the hard palate due to mucormycosis in a eight years child having acute lymphoblastic leukemia (ALL), who was on prolonged chemotherapy and corticosteroid therapy. This case is being reported for its rarity. The aim of presenting this case report is to emphasize that the infection due to mucomycosis should be included in the differential diagnosis of hard palate perforation in ALL patients who are immunocompromised.

摘要

腭部穿孔可因外伤、感染和恶性肿瘤引起。毛霉菌病是一种由接合菌纲生物引起的罕见机会性真菌感染。鼻脑型毛霉菌病是最常见的毛霉菌病类型,通常始于免疫功能低下患者的上颌窦。周围结构的侵犯导致硬腭坏死性溃疡,最终导致穿孔。在此,我们报告一例8岁急性淋巴细胞白血病(ALL)患儿因毛霉菌病导致硬腭穿孔的病例,该患儿正在接受长期化疗和皮质类固醇治疗。该病例因其罕见性而被报道。本病例报告的目的是强调在免疫功能低下的ALL患者中,毛霉菌病感染应纳入硬腭穿孔的鉴别诊断。

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引用本文的文献

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本文引用的文献

1
Mucormycosis presenting as palatal perforation.以腭部穿孔为表现的毛霉病。
Indian J Dent Res. 2006 Jul-Sep;17(3):139-42. doi: 10.4103/0970-9290.29873.
2
Mucormycosis: necrotizing soft tissue lesion of the face.毛霉病:面部坏死性软组织病变。
J Oral Maxillofac Surg. 2003 Nov;61(11):1354-8. doi: 10.1016/s0278-2391(03)00740-7.
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Mucormycosis: ten-year experience at a tertiary-care center in Greece.毛霉菌病:希腊一家三级医疗中心的十年经验
Eur J Clin Microbiol Infect Dis. 2003 Dec;22(12):753-6. doi: 10.1007/s10096-003-1035-y. Epub 2003 Nov 6.
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A case of maxillary necrosis.上颌骨坏死一例。
J Oral Maxillofac Surg. 2003 Apr;61(4):489-93. doi: 10.1053/joms.2003.50095.
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Aggressive destructive midfacial lesion from cocaine abuse.因可卡因滥用导致的侵袭性面部中部破坏性病变。
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Oct;94(4):465-70. doi: 10.1067/moe.2002.126020.
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Zygomycetes in human disease.人类疾病中的接合菌纲真菌。
Clin Microbiol Rev. 2000 Apr;13(2):236-301. doi: 10.1128/CMR.13.2.236.
9
Destructive midline palatal lesion.腭部中线破坏性病变。
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Feb;89(2):134-6. doi: 10.1067/moe.2000.104132.

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