Wesmiller S W, Hoffman L A, Sciurba F C, Ferson P F, Johnson J T, Dauber J H
School of Nursing, Department of Medicine, University of Pittsburg, Pennsylvania 15261.
Am Rev Respir Dis. 1990 Mar;141(3):789-91. doi: 10.1164/ajrccm/141.3.789.
Previous studies have reported that exercise tolerance improves with transtracheal oxygen delivery. However, patients were not blinded to the delivery technique used, introducing a potential source of bias. The purpose of this study was to compare exercise tolerance during nasal cannula and transtracheal delivery using a randomized double-blinded technique. Subjects (n = 11) performed 12-min walks on the same day while receiving nasal cannula and transtracheal delivery. Nine of 11 subjects walked farther with transtracheal delivery, a significant increase (p less than 0.01). Mean increase in walk distance was 95 +/- 86 feet. In addition, a trend was seen toward greater improvement in walk distance with greater flows through the catheter (r = 0.58, p less than 0.06). Time into the walk when desaturation (SaO2 less than 90%) first occurred was not significantly different. We conclude that exercise tolerance improves when oxygen is delivered by transtracheal catheter. This improvement is unrelated to an increase in SaO2. We speculate that the increase in exercise tolerance may be related to other physiologic effects of flow through the catheter.
以往的研究报告称，经气管给氧可提高运动耐力。然而，患者并未对所采用的给氧技术不知情，这引入了一个潜在的偏倚来源。本研究的目的是使用随机双盲技术比较鼻导管给氧和经气管给氧期间的运动耐力。受试者（n = 11）在同一天接受鼻导管给氧和经气管给氧时进行了12分钟的步行。11名受试者中有9名在经气管给氧时走得更远，有显著增加（p小于0.01）。步行距离的平均增加为95±86英尺。此外，随着通过导管的流量增加，步行距离有更大改善的趋势（r = 0.58，p小于0.06）。首次出现血氧饱和度降低（SaO2小于90%）时的步行时间没有显著差异。我们得出结论，经气管导管给氧时运动耐力会提高。这种改善与SaO2的增加无关。我们推测运动耐力的增加可能与通过导管的流量的其他生理效应有关。
