Ellis Harold
Department of Anatomy, University of London, Guy's Hospital, Guy's Campus, London SE1 1UL.
J Perioper Pract. 2012 Sep;22(9):298-9. doi: 10.1177/175045891202200906.
In 1932 Harvey Cushing published an article entitled 'Basophil adenomas of the pituitary and their clinical manifestations'. These are rare tumours of the anterior pituitary gland, at the base of the brain, with striking manifestations, which include adiposity of the face and trunk, but not the limbs, weakness, fatigue, abdominal striae, facial hair, high blood pressure and raised blood sugar. Although I spent two years in an army neurosurgical unit, I never saw a case. More frequently, the same clinical picture is produced by a benign adenoma of the suprarenal cortex, but today by far the commonest cause of this condition is seen in the patient receiving high dosage of cortisone, when we talk about the person exhibiting 'Cushingoid features'. Most readers of this journal will have seen such cases.
1932年，哈维·库欣发表了一篇题为《垂体嗜碱性腺瘤及其临床表现》的文章。这些是位于脑底部的垂体前叶的罕见肿瘤，具有显著的临床表现，包括面部和躯干肥胖，但四肢不胖、虚弱、疲劳、腹部条纹、面部多毛、高血压和血糖升高。尽管我在一个陆军神经外科单位工作了两年，但我从未见过一例。更常见的是，肾上腺皮质的良性腺瘤也会产生相同的临床症状，但如今，当我们谈到表现出“库欣样特征”的患者时，这种情况最常见的原因是患者接受了高剂量的可的松。本杂志的大多数读者可能都见过这样的病例。
