Palaniappa Nandini C, Doyon Laura, Divino Celia M
Department of Surgery, Division of General Surgery, Mount Sinai School of Medicine, New York, New York, USA.
Int Surg. 2012 Jan-Mar;97(1):14-6. doi: 10.9738/CC76.1.
Graft versus host disease (GVHD) is a phenomenon that occurs after allogeneic bone marrow transplants. Gastrointestinal (GI) manifestations of acute GVHD are common, but severe GI GVHD complications, such as bowel perforation, occur rarely and necessitate surgical intervention. To our knowledge, there are no recorded cases of colonic perforation resulting from GVHD with negative cultures for infectious agents such as cytomegalovirus. We present a case of large bowel perforation due to GVHD.
移植物抗宿主病（GVHD）是同种异体骨髓移植后发生的一种现象。急性GVHD的胃肠道表现很常见，但严重的胃肠道GVHD并发症，如肠穿孔，很少发生，需要手术干预。据我们所知，没有因GVHD导致结肠穿孔且感染因子（如巨细胞病毒）培养阴性的病例记录。我们报告一例因GVHD导致的大肠穿孔病例。
