斯里兰卡僧伽罗族女性子痫前期中血管内皮生长因子家族基因多态性
Vascular endothelial growth factor family gene polymorphisms in preeclampsia in Sinhalese women in Sri-Lanka.
作者信息
Andraweera Prabha H, Dekker Gustaaf A, Dissanayake Vajira H W, Bianco-Miotto Tina, Jayasekara Rohan W, Roberts Claire T
机构信息
Discipline of Obstetrics and Gynaecology, Robinson Institute, University of Adelaide, Adelaide, Australia.
出版信息
J Matern Fetal Neonatal Med. 2013 Mar;26(5):532-6. doi: 10.3109/14767058.2012.743520. Epub 2012 Nov 21.
OBJECTIVE
To investigate the association of polymorphisms in the vascular endothelial growth factor (VEGF) family genes (VEGFA rs699947, VEGFA rs3025039, PGF rs1042886, KDR rs2071559 and KDR rs2305948) with preeclampsia in Sinhalese women in Sri-Lanka.
METHODS
We conducted a case-control study where 175 nulliparous Sinhalese women with preeclampsia and 171 normotensive women matched for age, ethnicity, parity and BMI were recruited in tertiary care maternity hospitals in Sri-Lanka. Preeclampsia was diagnosed using international guidelines. DNA extracted from peripheral venous blood and was genotyped using the Sequenom MassARRAY system. χ(2)-test was used to compare the distribution of allele and genotype frequencies between the cases and the control subjects.
RESULTS
The frequency of PGF rs1042886 variant allele (odds ratio (OR) 1.5, 95% confidence interval (CI) 1.1-2.1) and dominant genotype model (aOR 1.6, 95% CI 1.0-2.4) were increased in preeclamptic women compared to controls. VEGFA rs699947, VEGFA rs3025039, KDR rs2071559, and KDR rs2305948 polymorphisms were not associated with preeclampsia.
CONCLUSION
Maternal PGF rs1042886 polymorphism is associated with preeclampsia in Sinhalese women in Sri-Lanka.
目的
研究血管内皮生长因子（VEGF）家族基因（VEGFA rs699947、VEGFA rs3025039、PGF rs1042886、KDR rs2071559和KDR rs2305948）多态性与斯里兰卡僧伽罗族女性先兆子痫的关联。
方法
我们进行了一项病例对照研究，在斯里兰卡的三级护理妇产医院招募了175例患有先兆子痫的未生育僧伽罗族女性和171例年龄、种族、胎次和BMI相匹配的血压正常女性。先兆子痫根据国际指南进行诊断。从外周静脉血中提取DNA，并使用Sequenom MassARRAY系统进行基因分型。采用χ²检验比较病例组和对照组之间等位基因和基因型频率的分布。
结果
与对照组相比，先兆子痫女性中PGF rs1042886变异等位基因频率（优势比（OR）1.5，95%置信区间（CI）1.1 - 2.1）和显性基因型模型（校正OR 1.6，95% CI 1.0 - 2.4）增加。VEGFA rs699947、VEGFA rs3025039、KDR rs2071559和KDR rs2305948多态性与先兆子痫无关。
结论
斯里兰卡僧伽罗族女性中，母体PGF rs1042886多态性与先兆子痫相关。
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