Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China.
Department of Gynecology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, P.R. China.
Biosci Rep. 2020 May 29;40(5). doi: 10.1042/BSR20190209.
Backgroud: Pre-eclampsia (PE) is a common pregnancy-induced hypertension disease. Some case-control studies reported the association between vascular endothelial growth factor (VEGF) gene polymorphisms (rs3025039, rs2010963) and PE risk. However, these associations were inconsistent in several studies. Therefore, we conducted this meta-analysis to assess the role of VEGF gene polymorphisms in PE more precisely.
Eligible studies were searched in PubMed, Embase, Web of Science and Chinese (Chinese National Knowledge Infrastructure (CNKI) and WanFang) databases. Statistical analyses were performed by Stata 12.0 software. Odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association. In addition, subgroup analyses, sensitive analyses and publication bias analyses were performed to further assess this meta-analysis.
In total, 21 studies were included in the meta-analysis covering 2018 cases and 2632 controls. There were significant associations between VEGF polymorphisms (rs3025039, rs2010963) and PE risk in the overall populations. In the subgroup analyses, we found that rs3025039 polymorphism was associated with the increased risk of PE among Chinese. As for rs2010963 polymorphism, a significant association was observed in subgroup of Caucasian.
The present study suggested that the two VEGF gene polymorphisms (rs3025039, rs2010963) are associated with increased risk of PE in different ethnic groups, which means that the targets may be useful genetic markers for early prediction of PE.
子痫前期（PE）是一种常见的妊娠高血压疾病。一些病例对照研究报道了血管内皮生长因子（VEGF）基因多态性（rs3025039、rs2010963）与 PE 风险之间的关联。然而，这些关联在几项研究中并不一致。因此，我们进行了这项荟萃分析，以更准确地评估 VEGF 基因多态性在 PE 中的作用。
在 PubMed、Embase、Web of Science 和中国（中国国家知识基础设施（CNKI）和万方）数据库中搜索符合条件的研究。使用 Stata 12.0 软件进行统计分析。使用优势比（OR）和 95%置信区间（CI）来评估关联的强度。此外，还进行了亚组分析、敏感性分析和发表偏倚分析，以进一步评估这项荟萃分析。
共有 21 项研究纳入了这项荟萃分析，涵盖了 2018 例病例和 2632 例对照。在总体人群中，VEGF 多态性（rs3025039、rs2010963）与 PE 风险之间存在显著关联。在亚组分析中，我们发现 rs3025039 多态性与中国人中 PE 风险增加有关。至于 rs2010963 多态性，在高加索人群亚组中观察到了显著的关联。
本研究表明，这两种 VEGF 基因多态性（rs3025039、rs2010963）与不同种族人群中 PE 风险增加有关，这意味着这些靶点可能是 PE 早期预测的有用遗传标志物。
