Frigo S, Malina C, Mathelin C
Unité de sénologie, pôle de gynécologie-obstétrique, CHRU de Strasbourg, avenue Molière, 67200 Strasbourg cedex, France.
Gynecol Obstet Fertil. 2012 Dec;40(12):784-6. doi: 10.1016/j.gyobfe.2012.09.005. Epub 2012 Oct 25.
Diethylstilbestrol (DES) is a synthetic estrogen prescribed to prevent miscarriages until 1977. Its role in the development of vaginal adenocarcinoma and cervical dysplasia is known and screening codified. Recent cohort studies show that exposure to DES in utero increases breast cancer risk especially after 40 years. This article reports the observation of a breast cancer of exceptional gravity in a patient exposed to DES in utero. It details the risk of breast cancer for "DES daughters" and support possible screening modalities.
己烯雌酚（DES）是一种合成雌激素，在1977年之前一直被用于预防流产。其在阴道腺癌和宫颈发育异常发展中的作用已为人所知，筛查方法也已规范化。最近的队列研究表明，子宫内接触DES会增加患乳腺癌的风险，尤其是在40岁之后。本文报告了一名子宫内接触DES的患者发生的一例极其严重的乳腺癌的观察情况。详细阐述了“DES女儿”患乳腺癌的风险，并支持可能的筛查方式。
