己烯雌酚暴露与透明细胞宫颈癌和阴道腺癌风险

Diethylstilbestrol exposure and the risk of clear cell cervical and vaginal adenocarcinoma.

作者信息

Edelman D A

机构信息

Medical Research Consultants, Inc., Chapel Hill, North Carolina.

出版信息

Int J Fertil. 1989 Jul-Aug;34(4):251-5.

PMID:2570761

Abstract

Data from two case-control studies that showed an association between in utero diethylstilbestrol (DES) exposure and clear cell vaginal cancer are evaluated. Neither study considered the cancer risk according to the reasons for prescribing DES and therefore cannot be used to infer any cause-and-effect relationship between DES exposure and vaginal cancer. Neither these studies nor any other studies have specifically evaluated the risk of clear cell cervical cancer to DES-exposed women. For DES-exposed women the risk of vaginal and cervical cancer is 0.5-2.0 cases per 1000 DES-exposed women; comparable data are not available for non-DES-exposed women.

摘要

对两项病例对照研究的数据进行了评估，这些数据显示子宫内己烯雌酚（DES）暴露与透明细胞阴道癌之间存在关联。两项研究均未根据开具DES的原因考虑癌症风险，因此无法用于推断DES暴露与阴道癌之间的任何因果关系。这些研究以及任何其他研究均未专门评估DES暴露女性患透明细胞宫颈癌的风险。对于DES暴露女性而言，每1000名DES暴露女性中阴道癌和宫颈癌的发病例数为0.5 - 2.0例；非DES暴露女性则没有可比数据。