School of Biological Sciences, The University of Queensland, Brisbane, St Lucia, QLD 4072, Australia.
Insect Biochem Mol Biol. 2013 Apr;43(4):388-97. doi: 10.1016/j.ibmb.2012.10.005. Epub 2012 Oct 26.
MicroRNAs (miRNAs) are small non-coding RNAs that are generated in all eukaryotes and viruses. Their role as master regulators of gene expression in various biological processes has only been fully appreciated over the last decade. Accumulating evidence suggests that alterations in the expression of miRNAs may lead to disorders, including developmental defects, diseases and cancer. Here, I review what is currently known about miRNA functions in insects to provide an insight into their diverse roles in insect biology.
MicroRNAs (miRNAs) 是在所有真核生物和病毒中产生的小型非编码 RNA。它们作为各种生物过程中基因表达的主要调控因子的作用仅在过去十年才得到充分认识。越来越多的证据表明,miRNA 表达的改变可能导致疾病,包括发育缺陷、疾病和癌症。在这里,我回顾了目前已知的 miRNA 在昆虫中的功能,以深入了解它们在昆虫生物学中的多种作用。