Lanzillotto Maria Paola, Orofino Antonio, Paradies Guglielmo, Zullino Francesca, Caroppo Francesco, Leggio Samuele
Ann Ital Chir. 2013 Nov-Dec;84(6):705-9.
In a female child presenting with vaginal bleeding or a mass protruding through the vagina, it is mandatory to perform an endoscopic and laparoscopic examination and biopsy to establish the correct diagnosis and precise extent of the lesion. An endodermal sinus tumor (EST) of the vagina is a rare, malignant germ cell tumor that occurs primarily in infants. Clearly, the vagina is a critical site for treatment, and the surgeon should seek to preserve the reproductive and sexual function, if possible. We report our experience of a case of EST of the vagina in a 9-month-old female with a history of metrorrhagia. We employed minimally invasive procedures for diagnosis and then, after the administration of platinum- based chemotherapy (PEB regimen), removed a residual lesion during follow-up. These procedures resulted in tumor regression. At follow-up, after two years, the patient is alive and disease-free.
对于出现阴道出血或有肿物经阴道突出的女童，必须进行内镜和腹腔镜检查及活检，以明确诊断并确定病变的准确范围。阴道内胚窦瘤（EST）是一种罕见的恶性生殖细胞肿瘤，主要发生于婴儿。显然，阴道是治疗的关键部位，外科医生应尽可能保留生殖和性功能。我们报告了一名9个月大、有子宫出血病史的女童阴道EST病例的治疗经验。我们采用微创手术进行诊断，然后在给予铂类化疗（PEB方案）后，在随访期间切除残留病变。这些操作导致肿瘤消退。随访两年后，患者存活且无疾病。
