肿瘤坏死因子-α（恶病质素）及肿瘤生长对大鼠肝脏氨基酸利用的影响
The effects of tumour necrosis factor-alpha (cachectin) and tumour growth on hepatic amino acid utilization in the rat.
作者信息
Argilés J M, López-Soriano F J
机构信息
Departament de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Spain.
出版信息
Biochem J. 1990 Feb 15;266(1):123-6. doi: 10.1042/bj2660123.
The effects of acute administration of tumour necrosis factor-alpha (cachectin) (TNF-alpha) or of malignant tumour growth (Walker-256 carcinosarcoma) on hepatic availability and uptake of individual amino acids were compared. The results show that, in spite of lowering the hepatic availability of alanine, aspartate, serine, glycine and proline, the cytokine increased both the total amino acid hepatic uptake and the individual uptakes of alanine, glutamate, serine, threonine, proline, lysine and arginine, while decreasing those of leucine, isoleucine and phenylalanine. Tumour burden resulted in an increase in the hepatic availability of glutamine, threonine, glycine, lysine, leucine, isoleucine, valine and phenylalanine. Total liver amino acid uptake was unaffected, whereas the individual uptakes of alanine, threonine and proline were increased and those of glutamate, glutamine, serine and leucine were decreased. When effects of the cytokine are compared with those induced by tumour growth, there are similar increases in net utilization for alanine, proline and leucine, and a 3-fold difference in the increase observed for threonine. Unmatched effects are seen for glutamate, glutamine, aspartate, glycine, lysine, arginine, valine, phenylalanine and serine.
比较了急性给予肿瘤坏死因子-α（恶病质素）（TNF-α）或恶性肿瘤生长（Walker-256癌肉瘤）对肝脏中单个氨基酸的可用性和摄取的影响。结果表明，尽管细胞因子降低了丙氨酸、天冬氨酸、丝氨酸、甘氨酸和脯氨酸的肝脏可用性，但它增加了肝脏对氨基酸的总摄取以及丙氨酸、谷氨酸、丝氨酸、苏氨酸、脯氨酸、赖氨酸和精氨酸的个体摄取，同时降低了亮氨酸、异亮氨酸和苯丙氨酸的摄取。肿瘤负荷导致谷氨酰胺、苏氨酸、甘氨酸、赖氨酸、亮氨酸、异亮氨酸、缬氨酸和苯丙氨酸的肝脏可用性增加。肝脏对氨基酸的总摄取未受影响，而丙氨酸、苏氨酸和脯氨酸的个体摄取增加，谷氨酸、谷氨酰胺、丝氨酸和亮氨酸的摄取减少。当将细胞因子的作用与肿瘤生长诱导的作用进行比较时，丙氨酸、脯氨酸和亮氨酸的净利用率有类似的增加，而苏氨酸的增加观察到有3倍的差异。谷氨酸、谷氨酰胺、天冬氨酸、甘氨酸、赖氨酸、精氨酸、缬氨酸、苯丙氨酸和丝氨酸的作用不匹配。
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