Bull Math Biol. 2012 Dec;74(12):2861-74. doi: 10.1007/s11538-012-9785-2. Epub 2012 Oct 27.
The molecular scaffold in the yeast pheromone pathway, Ste5, shuttles continuously between the nucleus and the cytoplasm. Ste5 undergoes oligomerization reaction in the nucleus. Upon pheromone stimulation, the Ste5 dimer is rapidly exported out of the nucleus and recruited to the plasma membrane for pathway activation. This clever device on part of the yeast cell is thought to prevent pathway misactivation at high enough levels of Ste5 in the absence of pheromone. We have built a spatiotemporal model of signaling in this pathway to describe its regulation. Our present work underscores the importance of spatial modeling of cell signaling networks to understand their control and functioning.
酵母信息素途径中的分子支架 Ste5 不断在细胞核和细胞质之间穿梭。Ste5 在细胞核中发生寡聚反应。在信息素刺激下，Ste5 二聚体迅速从细胞核输出，并被招募到质膜上以激活途径。酵母细胞的这一精巧设计被认为可以防止在没有信息素的情况下 Ste5 水平足够高时途径的错误激活。我们构建了该途径中信号转导的时空模型来描述其调控。我们目前的工作强调了对细胞信号网络进行空间建模以理解其控制和功能的重要性。
