Department of Dermatology and Venereology, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
J Infect Chemother. 2013 Aug;19(4):776-8. doi: 10.1007/s10156-012-0511-7. Epub 2012 Oct 28.
Penicillium marneffei infections in immunocompromised patients are often fatal, but early treatment with appropriate antifungal agents may have a good prognosis. To select drugs for treating P. marneffei infection in Southern China, the susceptibilities of antifungal agents against P. marneffei isolates were evaluated. Twenty-five strains of P. marneffei were isolated from patients from 2008 to 2010 in Guangxi Province of China, and 14 strains were isolated from bamboo rats. The activity of voriconazole, fluconazole, itraconazole, terbinafine, and amphotericin B on the isolates was assessed by MIC analysis. Voriconazole MIC against strains of P. marneffei ranged from 0.004 to 0.25 mg/l, and it had the lowest MIC (geometric mean values, 0.04 mg/l) in comparison to the other antifungal agents. The MICs of other antifungal agents, in order of lowest to highest, were as follows: itraconazole, terbinafine, amphotericin B, and fluconazole. The results show voriconazole and itraconazole are active against P. marneffei isolates in vitro, and terbinafine may have unrealized usefulness in the treatment of infections caused by this yeast form.
免疫功能低下患者感染马尔尼菲青霉通常是致命的，但早期使用适当的抗真菌药物治疗可能有良好的预后。为了选择药物治疗中国南方的马尔尼菲青霉感染，评估了抗真菌药物对马尔尼菲青霉分离株的敏感性。从 2008 年至 2010 年，从广西的患者中分离出 25 株马尔尼菲青霉，其中 14 株从竹鼠中分离。通过 MIC 分析评估了伏立康唑、氟康唑、伊曲康唑、特比萘芬和两性霉素 B 对分离株的活性。伏立康唑对马尔尼菲青霉株的 MIC 范围为 0.004 至 0.25mg/L，与其他抗真菌药物相比，其 MIC（几何均数，0.04mg/L）最低。其他抗真菌药物的 MIC 按从低到高的顺序排列如下：伊曲康唑、特比萘芬、两性霉素 B 和氟康唑。结果表明，伏立康唑和伊曲康唑对体外马尔尼菲青霉分离株具有活性，特比萘芬在治疗这种酵母形式引起的感染方面可能具有未实现的用途。
