Ashavaid T F, Shalia K K, Nair K G, Dalal J J
Research Laboratories, P.D. Hinduja National Hospital & Medical Research Centre, Veer Savarkar Marg, Mahim, 400 016 Mumbai.
Indian J Clin Biochem. 2000 Aug;15(Suppl 1):1-10. doi: 10.1007/BF02867539.
Coronary constriction, proliferation of smooth muscle cells and arrhythmia are involved in the pathophysiology of coronary heart disease and its complications such as myocardial infarction and sudden death. All these effects are favoured by high angiotensin II levels. Angiotensin II is the main effector molecule of the renin angiotensin system and it acts through angiotensin II type receptors. Genetically determined differences in the expression of the components of this system could adversely affect angiotensin II concentration and subsequently heart. Consequently each component of this system represents a potential candidate in the etiology of cardiovascular disease. In this article we review the variation of the angiotensin I converting enzyme, angiotensin II type I receptor and angiotensinogen genes and their association with cardiovascular disease.
冠状动脉收缩、平滑肌细胞增殖和心律失常参与了冠心病及其并发症（如心肌梗死和猝死）的病理生理过程。所有这些效应都受到高血管紧张素II水平的促进。血管紧张素II是肾素血管紧张素系统的主要效应分子，它通过血管紧张素II 1型受体发挥作用。该系统各组分表达的遗传决定差异可能会对血管紧张素II浓度产生不利影响，进而影响心脏。因此，该系统的每个组分都是心血管疾病病因学中的潜在候选因素。在本文中，我们综述了血管紧张素I转换酶、血管紧张素II 1型受体和血管紧张素原基因的变异及其与心血管疾病的关联。
