Khuller G K, Sharma S, Deo D
Department of Biochemistry, Postgraduate Institute of Medical Education & Research, 160012 Chandigarh.
Indian J Clin Biochem. 2000 Aug;15(Suppl 1):51-9. doi: 10.1007/BF02867544.
This review presents the extensive work carried out on lipid components of dermatophytes, their biosynthesis, turnover and regulation. It emerges from the work done so far that the pathways of lipid biosynthesis/ degradation and the lipid composition in dermatophytes are similar to those in yeasts and other fungi. Second messengers (Ca(2+), cAMP) were demonstrated to have a regulatory role in phospholipid metabolism and they mainly act by stimulating Ca(2+)/CaM or cAMP dependent protein kinase(s). Both these kinases were purified and characterized inMicrosporum gypseum. Further work is being carried out to elucidate the molecular mechanism of regulation of phospholipid metabolism by these second messengers.
本综述介绍了关于皮肤癣菌脂质成分、其生物合成、周转和调控方面所开展的大量工作。从目前已完成的工作可以看出,皮肤癣菌中脂质生物合成/降解途径以及脂质组成与酵母和其他真菌中的相似。已证明第二信使(Ca(2+)、cAMP)在磷脂代谢中具有调节作用,它们主要通过刺激Ca(2+)/CaM或cAMP依赖性蛋白激酶发挥作用。这两种激酶均已在石膏样小孢子菌中得到纯化和鉴定。目前正在开展进一步的工作以阐明这些第二信使对磷脂代谢调控的分子机制。