尿儿茶酚胺代谢产物：毛细管气相色谱法及12例神经母细胞瘤的经验
Urinary catecholamine metabolites: Capillary gas chromatography method and experience with 12 cases of neuroblastoma.
作者信息
Grkovic Sanja, Nikolic Rajko, Dordevic Maja, Stojanov Ljubomir
机构信息
Department of Pediatrics, Mother and Child Health Care Institute of Serbia, Belgrade, Yugoslavia.
出版信息
Indian J Clin Biochem. 2005 Jul;20(2):178-81. doi: 10.1007/BF02867423.
We propose a rapid, simple metodology for routine analysis of human urine to detect vanillylmandelic and homovanillic acid related to neuroblastoma. The assay were specific capillary gas chromatography with flame ionization detection. In this methodology an internal standard is used and the procedure involves ethyl ester formation without isolation of the compounds of interest. The run time is 36 minutes. We also report quantitative results for urinary vanillylmandelic and homovanillic acid in neuroblastoma patients, demonstrating the diagnostic value of this method.
我们提出了一种快速、简单的方法，用于对人尿液进行常规分析，以检测与神经母细胞瘤相关的香草扁桃酸和高香草酸。该测定法为具有火焰离子化检测的特定毛细管气相色谱法。在该方法中使用了内标，并且该程序涉及在不分离目标化合物的情况下形成乙酯。运行时间为36分钟。我们还报告了神经母细胞瘤患者尿液中香草扁桃酸和高香草酸的定量结果，证明了该方法的诊断价值。
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