尿中3-甲氧基-4-羟基苯乙酸（高香草酸）和3-甲氧基-4-羟基扁桃酸（香草扁桃酸）：气液色谱法及13例神经母细胞瘤的经验
Urinary 3-methoxy-4-hydroxyphenylacetic (homovanillic) and 3-methoxy-4-hydroxymandelic (vanillylmandelic) acids: gas-liquid chromatographic methods and experience with 13 cases of neuroblastoma.
作者信息
Brewster M A, Berry D H, Moriarty M
出版信息
Clin Chem. 1977 Dec;23(12):2247-9.
We present a quantitative gas-chromatographic method for determining urinary 3-methoxy-4-hydroxymandelic acid (vanillylmandelic acid) and 3-methoxy-4-hydroxyphenylacetic acid (homovanillic acid). In this rapid technique an internal standard is used and the procedure involves ether extraction and silyl ether formation. Analytical recovery of vanillylmandelic acid averages 87.5% (CV, 0.95%), of homovanillic acid 102.3% (CV, 9.95%). Our data on 34 samples from 13 neuroblastoma patients show that homovanillic acid is more consistently elevated than is vanillylmandelic acid.
我们提出一种定量气相色谱法，用于测定尿中的3-甲氧基-4-羟基扁桃酸（香草扁桃酸）和3-甲氧基-4-羟基苯乙酸（高香草酸）。在这种快速技术中使用了内标，该方法包括乙醚萃取和甲硅烷基醚的形成。香草扁桃酸的分析回收率平均为87.5%（变异系数，0.95%），高香草酸为102.3%（变异系数，9.95%）。我们对13例神经母细胞瘤患者的34份样本的数据表明，高香草酸比香草扁桃酸更持续地升高。
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