镁对甲状旁腺激素分泌及作用的影响。

Influence of magnesium on the secretion and action of parathyroid hormone.

作者信息

Nair K S, Holdaway I M, Evans M C, Cameron A D

出版信息

J Endocrinol Invest. 1979 Jul-Sep;2(3):267-70. doi: 10.1007/BF03350414.

Abstract

The interactions of serum levels of magnesium and parathyroid hormone (PTH) have been studied in a patient with hypomagnesemia and hypocalcemia following intestinal bypass surgery for obesity. When serum magnesium was low serum PTH was not stimulated by hypocalcemia. With correction of magnesium deficiency hypocalcemia was associated with elevation of serum PTH levels. Infusion of exogenous PTH induced a clearly detectable renal response in the presence of hypomagnesemia but the response was diminished when serum magnesium was elevated. In this patient it appears that hypomagnesemia suppressed parathyroid gland activity, leaving the renal action of PTH intact.

摘要

对一名因肥胖接受肠道搭桥手术后出现低镁血症和低钙血症的患者，研究了血清镁水平与甲状旁腺激素（PTH）之间的相互作用。当血清镁水平较低时，低钙血症不会刺激血清PTH升高。随着镁缺乏的纠正，低钙血症与血清PTH水平升高相关。在低镁血症情况下，输注外源性PTH可诱导明显可检测到的肾脏反应，但当血清镁水平升高时，该反应会减弱。在该患者中，似乎低镁血症抑制了甲状旁腺的活性，而PTH的肾脏作用保持完好。