一项针对早发性银屑病患者类风湿关节炎基因座的研究验证了 REL 基因的相关性。
An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene.
机构信息
The Dermatology Centre, Salford Royal NHS Foundation Trust, University of Manchester, Manchester M6 8HD, UK.
出版信息
Br J Dermatol. 2013 Apr;168(4):864-6. doi: 10.1111/bjd.12106. Epub 2013 Feb 27.
BACKGROUND
Phenotypically diverse autoimmune conditions share common genetic susceptibility loci and underlying molecular pathways.
OBJECTIVES
By systematically searching for single nucleotide polymorphisms (SNPs) associated with another autoimmune disease, rheumatoid arthritis (RA), we aimed to elucidate novel genetic markers of psoriasis.
METHODS
We investigated 18 SNPs, previously confirmed as being associated with RA, in a U.K. cohort of 623 patients with early-onset psoriasis (presenting before age 40 years), comparing them with 2662 control subjects.
RESULTS
Our findings confirm the association of early-onset psoriasis with REL (rs13031237, P=0·0027). The minor allele of REL had opposing effects upon susceptibility to disease in patients with psoriasis and RA.
CONCLUSION
Similar exploration of additional autoimmune loci and fine mapping of such regions may provide further insight into the genetics and molecular pathophysiology of psoriasis.
背景
表型多样的自身免疫性疾病具有共同的遗传易感性位点和潜在的分子途径。
目的
通过系统地搜索与另一种自身免疫性疾病类风湿关节炎（RA）相关的单核苷酸多态性（SNP），我们旨在阐明银屑病的新的遗传标志物。
方法
我们在一个英国队列中调查了 623 名早发性银屑病（发病年龄<40 岁）患者中的 18 个 SNP，将其与 2662 名对照进行比较。
结果
我们的研究结果证实了早发性银屑病与 REL（rs13031237，P=0.0027）的相关性。REL 的次要等位基因对银屑病和 RA 患者的疾病易感性有相反的影响。
结论
对其他自身免疫性基因座的类似探索和这些区域的精细作图可能会进一步深入了解银屑病的遗传学和分子病理生理学。
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