Okahata H, Nishi Y, Mizoguchi N, Yumiba C, Fujii H, Ueda K
Department of Pediatrics, Ohtake National Hospital, Japan.
Clin Exp Allergy. 1990 Jan;20(1):39-44. doi: 10.1111/j.1365-2222.1990.tb02773.x.
Dermatophagoides farinae-, ovalbumin- and lactalbumin-specific IgG, IgG1, IgG4, IgA and IgM were evaluated in 161 healthy children [Group 1], 84 children with bronchial asthma and/or allergic rhinitis but without atopic dermatitis [Group 2], and 54 children with atopic dermatitis but without bronchial asthma and allergic rhinitis [Group 3]. We also studied D. farinae-, egg-white-, and milk-specific IgE of children with allergic diseases. D. farinae-specific IgG, IgG1, IgG4 and IgA in Groups 2 and 3 increased until 5 years of age and thereafter they remained constant. After 2 years of age, D. farinae-specific IgG, IgG1, IgG4 and IgA in Group 2 were higher than those in Groups 1 and 3. Ovalbumin- and lactalbumin-specific IgG, IgG1, IgG4 and IgA in Groups 2 and 3 increased until 1 year of age and thereafter decreased. Until 1 year of age, ovalbumin- and lactalbumin-specific IgG, IgG1 and IgG4 in Groups 3 were higher than those in Groups 1 and 2. D. farinae-, ovalbumin- and lactalbumin-specific IgM were constant in all ages of all groups. These results suggest that atopic dermatitis in young children is related to food-specific immunoglobulins and that respiratory allergic diseases in older children is related to D. farinae-specific immunoglobulins.
在161名健康儿童（第1组）、84名患有支气管哮喘和/或过敏性鼻炎但无特应性皮炎的儿童（第2组）以及54名患有特应性皮炎但无支气管哮喘和过敏性鼻炎的儿童（第3组）中，评估了针对粉尘螨、卵清蛋白和乳白蛋白的IgG、IgG1、IgG4、IgA和IgM。我们还研究了过敏性疾病儿童的粉尘螨、蛋清和牛奶特异性IgE。第2组和第3组中粉尘螨特异性IgG、IgG1、IgG4和IgA在5岁前升高，此后保持稳定。2岁后，第2组中粉尘螨特异性IgG、IgG1、IgG4和IgA高于第1组和第3组。第2组和第3组中卵清蛋白和乳白蛋白特异性IgG、IgG1、IgG4和IgA在1岁前升高，此后下降。1岁前，第3组中卵清蛋白和乳白蛋白特异性IgG、IgG1和IgG4高于第1组和第2组。所有组各年龄段中粉尘螨、卵清蛋白和乳白蛋白特异性IgM均保持稳定。这些结果表明，幼儿特应性皮炎与食物特异性免疫球蛋白有关，而大龄儿童的呼吸道过敏性疾病与粉尘螨特异性免疫球蛋白有关。
