Akkara Veetil Bharath Manu, Matteson Eric L, Maradit-Kremers Hilal, McEvoy Marian T, Crowson Cynthia S
Division of Rheumatology, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
BMC Dermatol. 2012 Oct 30;12:20. doi: 10.1186/1471-5945-12-20.
Psoriasis is associated with an atherogenic lipid profile but longitudinal changes in lipids around disease onset are unknown. The purpose of our study is to examine the effect of psoriasis onset on serum lipid profiles.
We compared changes in lipid profiles in a population based incident cohort of 689 patients with psoriasis and 717 non-psoriasis subjects. All lipid measures performed 5 years before and after psoriasis incidence/index date were abstracted. Random-effects models adjusting for age, sex and calendar year were used to examine trends in lipid profiles.
There were significant declines in total cholesterol (TC) and low-density lipoprotein (LDL) levels during the 5 years before and after psoriasis incidence/index date in both the psoriasis and the non-psoriasis cohorts, with a greater decrease noted in the TC levels (p=0.022) and LDL (p=0.054) in the non-psoriasis cohort. High-density lipoprotein (HDL) levels increased significantly both before and after psoriasis incidence date in the psoriasis cohort. Triglyceride (TG) levels were significantly higher (p<0.001), and HDL levels significantly lower (p=0.013) in patients with psoriasis compared to non-psoriasis subjects. There were no differences in prescriptions for lipid lowering drugs between the two cohorts.
Patients with psoriasis had a significant decrease in TC and LDL levels during the 5 years before psoriasis incidence. Higher mean TG and lower mean HDL levels were noted in the 5 years before psoriasis incidence. These changes are unlikely to be caused by lipid lowering treatment alone and require further exploration.
银屑病与致动脉粥样硬化的血脂谱相关，但疾病发作前后血脂的纵向变化尚不清楚。我们研究的目的是检验银屑病发作对血清血脂谱的影响。
我们比较了689例银屑病患者和717例非银屑病受试者的基于人群的发病队列中的血脂谱变化。提取了银屑病发病/索引日期前后5年进行的所有血脂测量值。使用调整年龄、性别和日历年份的随机效应模型来检验血脂谱的趋势。
银屑病队列和非银屑病队列在银屑病发病/索引日期前后5年期间，总胆固醇（TC）和低密度脂蛋白（LDL）水平均显著下降，非银屑病队列中TC水平（p=0.022）和LDL水平（p=0.054）下降幅度更大。银屑病队列中高密度脂蛋白（HDL）水平在银屑病发病日期前后均显著升高。与非银屑病受试者相比，银屑病患者的甘油三酯（TG）水平显著更高（p<0.001），HDL水平显著更低（p=0.013）。两个队列之间降脂药物的处方没有差异。
银屑病患者在银屑病发病前5年期间TC和LDL水平显著下降。在银屑病发病前5年期间，平均TG水平更高，平均HDL水平更低。这些变化不太可能仅由降脂治疗引起，需要进一步探索。
