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髋部骨折修复术后心肌梗死:一项基于人群的研究。

Myocardial infarction after hip fracture repair: a population-based study.

机构信息

Divisions of Hospital Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

出版信息

J Am Geriatr Soc. 2012 Nov;60(11):2020-6. doi: 10.1111/j.1532-5415.2012.04205.x. Epub 2012 Oct 30.

Abstract

OBJECTIVES

To quantify the occurrence of myocardial infarction (MI) occurring in the early postoperative period after surgical hip fracture repair and estimate the effect on 1-year mortality.

DESIGN

A population-based, historical cohort study of individuals who underwent surgical repair of a hip fracture that used the computerized medical record linkage system of the Rochester Epidemiology Project.

SETTING

Academic and community hospitals, outpatient offices, and nursing homes in Olmsted County, Minnesota.

PARTICIPANTS

Over the 15-year study period (1988-2002), 1,116 elderly adults underwent surgical repair of a hip fracture.

MEASUREMENTS

At the end of the first 7 days after hip fracture repair, participants were classified into one of three groups: clinically verified MI (cv-MI), subclinical myocardial ischemia, and no myocardial ischemia. One-year mortality was compared between these groups. Multivariate models assessed risk factors for early postoperative cv-MI and 1-year mortality.

RESULTS

Within the first 7 days after hip fracture repair, 116 (10.4%) participants experienced cv-MI and 41 (3.7%) subclinical myocardial ischemia. Overall 1-year mortality was 22%, with no difference between those with subclinical myocardial ischemia and those with no myocardial ischemia. One-year mortality for those with cv-MI (35.8%) was significantly higher than for the other two groups. Occurrence of early postoperative cv-MI, male sex, and history of heart failure or dementia were independently associated with greater 1-year mortality, whereas prefracture home residence and preoperative higher hemoglobin were protective.

CONCLUSION

Rates of early postoperative, cv-MI after hip fracture repair exceed rates after other major orthopedic surgeries and are independently associated with greater 1-year mortality.

摘要

目的

定量分析髋关节骨折手术后早期发生心肌梗死(MI)的情况,并评估其对 1 年死亡率的影响。

设计

这是一项基于人群的历史队列研究,研究对象为在明尼苏达州罗彻斯特流行病学项目的计算机医疗记录链接系统接受髋关节骨折手术修复的个体。

地点

明尼苏达州奥姆斯特德县的学术和社区医院、门诊办公室和疗养院。

参与者

在 15 年的研究期间(1988-2002 年),有 1116 名老年人接受了髋关节骨折的手术修复。

测量

在髋关节骨折修复后的头 7 天结束时,参与者被分为三组之一:临床证实的 MI(cv-MI)、亚临床心肌缺血和无心肌缺血。比较这些组之间的 1 年死亡率。多变量模型评估了术后早期 cv-MI 和 1 年死亡率的危险因素。

结果

在髋关节骨折修复后的头 7 天内,116 名(10.4%)参与者发生了 cv-MI,41 名(3.7%)发生了亚临床心肌缺血。总的 1 年死亡率为 22%,亚临床心肌缺血组和无心肌缺血组之间无差异。cv-MI 组(35.8%)的 1 年死亡率明显高于其他两组。术后早期 cv-MI 的发生、男性、心力衰竭或痴呆史与更高的 1 年死亡率独立相关,而术前居住地和较高的血红蛋白水平则具有保护作用。

结论

髋关节骨折手术后早期 cv-MI 的发生率高于其他主要骨科手术后的发生率,与更高的 1 年死亡率独立相关。

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