Ghana-Michigan Charter, C/O Office of the Provost, College of Health Sciences, University of Ghana, P, O, Box KB 52, Korle-Bu, Ghana.
BMC Endocr Disord. 2012 Oct 30;12:25. doi: 10.1186/1472-6823-12-25.
The Metabolic syndrome (MS) which is a constellation of cardiometabolic risk factors including dyslipidaemia, hypertension, hyperglycaemia, central obesity, and endothelial dysfunction was hitherto relatively uncommon among Africans south of the Sahara. This study seeks to determine the prevalence of MS, its components and risk factors among a rural population in Ghana based on two popular international algorithms.
This was a cross-sectional survey of a rural population in Ghana conducted between November and December, 2007. Two hundred and twenty-eight (228) settler farmers, families and staff associated with the GOPDC Ltd, between the ages of 35 and 64 years, were randomly selected for the study; pregnant women were excluded. The prevalence of MS was estimated using the IDF and ATPIII criteria.
The final subject pool included 102 males, and 104 females. The mean age of all subjects was 44.4 ± 6.9 years. The overall prevalence of MS by the IDF and ATPIII criteria were 35.9% and 15.0%, respectively, but there was an alarming female preponderance by both criteria {IDF: males = 15.7%, females =55.8%; ATPIII: males = 5.9%, females = 24.0%; sex differences p<0.001 for both criteria}. The most important determinants for IDF-defined MS were central obesity (55.3%), low High Density Lipoprotein (42.7%) and high Blood Pressure (39.5%).
The triad of central obesity, high blood pressure and low HDL were most responsible for the syndrome in this rural population.
代谢综合征（MS）是一组心血管代谢危险因素的综合征，包括血脂异常、高血压、高血糖、中心性肥胖和内皮功能障碍，此前在撒哈拉以南的非洲人中相对少见。本研究旨在根据两种流行的国际算法，确定加纳农村人口中 MS 的患病率、其组成部分和危险因素。
这是 2007 年 11 月至 12 月期间在加纳农村进行的一项横断面调查。从 GOPDC Ltd 的 228 名定居农民、家庭和员工中随机选择年龄在 35 至 64 岁之间的 228 名参与者；排除孕妇。使用 IDF 和 ATPIII 标准估计 MS 的患病率。
最终的研究对象包括 102 名男性和 104 名女性。所有受试者的平均年龄为 44.4 ± 6.9 岁。根据 IDF 和 ATPIII 标准，MS 的总患病率分别为 35.9%和 15.0%，但两种标准均显示出惊人的女性优势{IDF：男性=15.7%，女性=55.8%；ATPIII：男性=5.9%，女性=24.0%；两种标准的性别差异均为 p<0.001}。IDF 定义的 MS 的最重要决定因素是中心性肥胖（55.3%）、低高密度脂蛋白（42.7%）和高血压（39.5%）。
在这个农村人群中，中心性肥胖、高血压和低 HDL 是导致该综合征的三联征。
