Neal D E, Sharples L, Smith K, Fennelly J, Hall R R, Harris A L
University Department of Surgery, University of Newcastle upon Tyne, England.
Cancer. 1990 Apr 1;65(7):1619-25. doi: 10.1002/1097-0142(19900401)65:7<1619::aid-cncr2820650728>3.0.co;2-q.
Epidermal growth factor is found in high concentrations in urine, and its receptor (EGFr) has been identified in certain bladder tumors. This study was performed to determine whether receptor positivity in the tumor was associated with a poor clinical outcome. One hundred one patients with newly diagnosed bladder cancer were studied prospectively by immunohistochemical staining for the EGFr. There were 76 men and 25 women, with a mean follow-up of 30 months; 49 had tumors invading muscle: 18 were pTl (tumor invading lamina propia) and 34 were pTa (tumor confined to urothelium). Strong staining for the EGFr was found in 48% of tumors and was associated with high stage (P less than 0.001). Death of bladder cancer (40 of 101) was associated independently with high stage (P less than 0.0001) and EGFr positivity (P less than 0.001). In patients with pTa and pTl tumors, EGFr positivity was associated with multiplicity (P less than 0.01), time to recurrence (P less than 0.03), and recurrence rate (P less than 0.004). Tumor progression was associated with EGFr positivity (P less than 0.0001) and multiplicity (P less than 0.05). EGFr were found on a significant proportion of bladder tumors: such tumors were more likely to result in death, recurrence, and progression.
表皮生长因子在尿液中含量很高，其受体（EGFr）已在某些膀胱肿瘤中被鉴定出来。本研究旨在确定肿瘤中的受体阳性是否与不良临床结果相关。通过对EGFr进行免疫组织化学染色，对101例新诊断的膀胱癌患者进行了前瞻性研究。其中男性76例，女性25例，平均随访30个月；49例肿瘤侵犯肌肉：18例为pTl（肿瘤侵犯固有层），34例为pTa（肿瘤局限于尿路上皮）。48%的肿瘤中发现EGFr强染色，且与高分期相关（P<0.001）。膀胱癌死亡（101例中的40例）独立地与高分期（P<0.0001）和EGFr阳性（P<0.001）相关。在pTa和pTl肿瘤患者中，EGFr阳性与肿瘤多灶性（P<0.01）、复发时间（P<0.03）和复发率（P<0.004）相关。肿瘤进展与EGFr阳性（P<0.0001）和多灶性（P<0.05）相关。相当比例的膀胱肿瘤中发现有EGFr：这类肿瘤更有可能导致死亡、复发和进展。
