意大利浸润性宫颈癌中 HPV 型别分布：三项大型研究的汇总分析。
HPV type distribution in invasive cervical cancers in Italy: pooled analysis of three large studies.
机构信息
AUSL Reggio Emilia, via Amendola 2, Reggio Emilia, 42122, Italy.
出版信息
Infect Agent Cancer. 2012 Oct 12;7(1):26. doi: 10.1186/1750-9378-7-26.
OBJECTIVE
The aim of this study is to describe the prevalence of HPV types in invasive cervical cancers in Italy from 1996 to 2008.
METHODS
A pooled analysis of the three largest case series typed to date was performed. HPV typing was performed on paraffin-embedded slices. Molecular analyses were performed in four laboratories. Multivariate analyses were performed to test the associations between calendar time, age, and geographical area and the proportion of types 16/18.
RESULTS
Out of 574 cancers, 24 (4.2%) were HPV negative. HPV 16 and 18 were responsible for 74.4% (378/508) and 80.3% (49/61) of the squamous cancers and adenocarcinomas, respectively. Other frequent types were 31 (9.5%), 45 (6.4%), and 58 (3.3%) for squamous cancers and 45 (13.3%), 31, 35, and 58 (5.0%) for adenocarcinomas. The proportion of HPV 16 and/or 18 decreased with age (p-value for trend <0.03), while it increased in cancers diagnosed in more recent years (p-value for trend < 0.005).
CONCLUSIONS
The impact of HPV 16/18 vaccine on cervical cancer will be greater for early onset cancers. In vaccinated women, screening could be started at an older age without reducing protection.
目的
本研究旨在描述 1996 年至 2008 年意大利浸润性宫颈癌中 HPV 型别的流行情况。
方法
对迄今为止已分型的三个最大病例系列进行了汇总分析。对石蜡包埋切片进行 HPV 分型。在四个实验室进行分子分析。进行多变量分析以检验 HPV 16/18 型在时间、年龄和地理区域之间的关联。
结果
在 574 例癌症中，有 24 例（4.2%）HPV 阴性。HPV 16 和 18 分别导致 74.4%（378/508）和 80.3%（49/61）的鳞癌和腺癌，其他常见的型别分别为 31 型（9.5%）、45 型（6.4%）和 58 型（3.3%），以及 45 型（13.3%）、31 型、35 型和 58 型（5.0%）。HPV 16 和/或 18 的比例随年龄的增加而降低（趋势检验 p 值<0.03），而在近年诊断的癌症中则增加（趋势检验 p 值<0.005）。
结论
HPV 16/18 疫苗对宫颈癌的影响将在发病年龄较早的癌症中更大。在接种疫苗的女性中，筛查可以在更大的年龄开始，而不会降低保护作用。
Zotero 插件