比较毛细血管血中校正后的离子钙（pH 7.4时）和实际离子钙（实际pH时），以对钙代谢紊乱患者进行临床评估。

Adjusted ionized calcium (at pH 7.4) and actual ionized calcium (at actual pH) in capillary blood compared for clinical evaluation of patients with disorders of calcium metabolism.

作者信息

Thode J, Holmegaard S N, Transbøl I, Fogh-Andersen N, Siggaard-Andersen O

机构信息

Department of Clinical Chemistry, Herlev Hospital, University of Copenhagen, Denmark.

出版信息

Clin Chem. 1990 Mar;36(3):541-4.

PMID:2311230

Abstract

We report results for adjusted ionized calcium (at pH 7.4) and actual ionized calcium (at actual pH) in capillary blood from 183 patients with disorders of calcium metabolism (primary hyperparathyroidism, secondary hyperparathyroidism of malabsorption, primary hypoparathyroidism, Paget's disease, acromegaly, hypercalcemia of malignancy, osteoporosis, sarcoidosis, idiopathic hypercalciuria, and familial hypocalciuric hypercalcemia). The correlation and the equation for the linear regression between adjusted ionized calcium (y) and actual ionized calcium (x) were y = 1.011x + 0.005 mmol/L, r = 0.992, Sy,x = 0.021 mmol/L. Results were similar within each diagnostic group. Consistent agreement between adjusted and ionized calcium was observed in 96.7% of patients representing a variety of the most frequently encountered disorders of calcium metabolism. Thus we find adjusted ionized calcium to be as useful as actual ionized calcium for evaluation of patients with such disorders. Adjusted ionized calcium may therefore also be a logical choice for establishing agreement between laboratories for reference intervals in healthy adults.

摘要

我们报告了183例钙代谢紊乱患者（原发性甲状旁腺功能亢进、吸收不良所致继发性甲状旁腺功能亢进、原发性甲状旁腺功能减退、佩吉特病、肢端肥大症、恶性肿瘤高钙血症、骨质疏松症、结节病、特发性高钙尿症和家族性低钙血症性高钙血症）毛细血管血中校正离子钙（pH 7.4时）和实际离子钙（实际pH时）的检测结果。校正离子钙（y）与实际离子钙（x）之间的线性回归相关性及方程为y = 1.011x + 0.005 mmol/L，r = 0.992，Sy,x = 0.021 mmol/L。各诊断组内结果相似。在代表各种最常见钙代谢紊乱的患者中，96.7%观察到校正钙与离子钙一致。因此，我们发现校正离子钙在评估此类疾病患者时与实际离子钙一样有用。因此，校正离子钙也可能是建立健康成年人实验室参考区间一致性的合理选择。