伊朗德黑兰HIV感染者中GBV-C RNA的流行情况。
Prevalence of GBV-C RNA in HIV infected individuals in Tehran, Iran.
作者信息
Keyvani H, Mohammadi A, Haji-Abdolbaghi M
机构信息
Dept. of Virology, School of Medicine, Iran University of Medical sciences, Iran.
出版信息
Iran J Public Health. 2010;39(1):22-7. Epub 2010 Mar 31.
BACKGROUND
GB virus C (GBV-C) is a flavivirus that was characterized in 1995. The prevalence of GBV-C RNA in HIV-infected subjects has not been previously studied in Iran and was therefore determined.
METHODS
We have investigated serum samples of 80 patients from Imam Khomeini Hospital, Tehran, Iran, whose HIV infection was confirmed in our laboratory by Western-blotting. We used nested-PCR to detect GBV-C/HGV RNA in their sera.
RESULTS
GBV-C/HGV RNA was detected in 15 (18.8%) of 80 patients. There was no significant difference in GBV-C/HGV RNA prevalence between males and females, in different age groups and HIV viral loads groups.
CONCLUSION
The prevalence of GBV-C RNA was high in HIV-infected patients. There was no association between GBV-C RNA prevalence and specific gender, age, and HIV viral loads groups.
背景
GB病毒C（GBV-C）是一种黄病毒，于1995年被鉴定。此前伊朗尚未对HIV感染患者中GBV-C RNA的流行情况进行研究，因此我们对此进行了测定。
方法
我们调查了伊朗德黑兰伊玛目霍梅尼医院80例患者的血清样本，这些患者的HIV感染在我们实验室通过免疫印迹法得以确认。我们采用巢式PCR检测他们血清中的GBV-C/HGV RNA。
结果
80例患者中有15例（18.8%）检测到GBV-C/HGV RNA。男性与女性之间、不同年龄组以及HIV病毒载量组之间GBV-C/HGV RNA的流行率无显著差异。
结论
HIV感染患者中GBV-C RNA的流行率较高。GBV-C RNA流行率与特定性别、年龄及HIV病毒载量组之间无关联。
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