丙型GB病毒/庚型肝炎病毒：一种与HIV感染个体长期存活相关的非致病性黄病毒。

GB virus type C/hepatitis G virus: a non-pathogenic flavivirus associated with prolonged survival in HIV-infected individuals.

作者信息

Polgreen Philip M, Xiang Jinhua, Chang Qing, Stapleton Jack T

机构信息

Department of Internal Medicine, Iowa City VA Medical Center, Internal Medicine SW34-P, GH, University of Iowa, UIHC, 200 Hawkins Drive, Iowa City, IA 52242, USA.

出版信息

Microbes Infect. 2003 Nov;5(13):1255-61. doi: 10.1016/j.micinf.2003.08.006.

DOI:10.1016/j.micinf.2003.08.006

PMID:14623022

Abstract

GB virus C (GBV-C) is a common virus that does not appear to cause disease. GBV-C persists in up to 50% of exposed individuals, and virus replication appears to be in lymphocytes including CD4+ T cells. GBV-C infection is common among HIV-positive people, and several studies have found that HIV-positive individuals co-infected with GBV-C survive for statistically significantly longer periods of time than people without GBV-C. In vitro studies suggest that GBV-C inhibits HIV replication and alters cytokine, chemokine and chemokine receptor expression. Thus, GBV-C may be a major factor influencing the natural history of HIV disease.

摘要

丙型肝炎病毒（GBV-C）是一种常见病毒，似乎不会引发疾病。GBV-C在高达50%的暴露个体中持续存在，病毒复制似乎发生在包括CD4 + T细胞在内的淋巴细胞中。GBV-C感染在艾滋病毒阳性人群中很常见，多项研究发现，与未感染GBV-C的人相比，同时感染GBV-C的艾滋病毒阳性个体存活时间在统计学上显著更长。体外研究表明，GBV-C可抑制艾滋病毒复制，并改变细胞因子、趋化因子和趋化因子受体的表达。因此，GBV-C可能是影响艾滋病毒疾病自然病程的一个主要因素。