大鼠中化合物M-11及其代谢产物在尿液和粪便中的排泄情况。

Excretion of compound M-11 and its metabolites with urine and feces in rats.

作者信息

Bastrygin D V, Viglinskaya A O, Kolyvanov G B, Litvin A A, Bochkov P O, Mozhaeva T Ya, Zherdev V P

机构信息

Laboratory of Pharmacokinetics, VV Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2012 Sep;153(5):707-9. doi: 10.1007/s10517-012-1805-6.

DOI:10.1007/s10517-012-1805-6

PMID:23113264

Abstract

The excretion of compound M-11 and its metabolites with the urine and feces was studied in rats after intraperitoneal and oral administration in a dose of 25 mg/kg. Experiments showed that 1% metabolites were detected in excretions over 24 h irrespective of the route of administration, while the initial compound was not found even in trace amounts.

摘要

在大鼠腹腔注射和口服25mg/kg剂量后，研究了化合物M-11及其代谢产物在尿液和粪便中的排泄情况。实验表明，无论给药途径如何，在24小时的排泄物中均检测到1%的代谢产物，而即使是痕量也未发现初始化合物。