阿伏唑和化合物M-11的组织可用性比较分析。
Comparative analysis of tissue availability for afobazole and compound M-11.
作者信息
Viglinskaya A O, Bastrygin D V, Kolyvanov G B, Litvin A A, Zherdev V P, Mozhaeva T Ya
机构信息
V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2010 Sep;149(3):318-9. doi: 10.1007/s10517-010-0936-x.
Comparative analysis of pharmacokinetic parameters of afobazole and its main metabolite M-11 after single intraperitoneal injections of their solutions (25 mg/kg) to rats showed much more intense penetration of M-11 compared to afobazole into rat tissues and organs, judging from the area under the pharmacokinetic curve (AUC) and maximum concentrations (C(max)). The half-life periods (T(l/2e)l) of afobazole and M-11 were similar.
给大鼠单次腹腔注射阿伏苯唑及其主要代谢物M-11的溶液（25毫克/千克）后，对其药代动力学参数进行比较分析，从药代动力学曲线下面积（AUC）和最大浓度（C(max)）判断，与阿伏苯唑相比，M-11在大鼠组织和器官中的渗透更为强烈。阿伏苯唑和M-11的半衰期（T(l/2e)l）相似。
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