Juneja R, Gupta I, Wali A, Sanyal S N, Chakravarti R N, Majumdar S
Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Contraception. 1990 Feb;41(2):179-87. doi: 10.1016/0010-7824(90)90146-m.
Verapamil, a calcium channel blocker, was administered orally using three different doses to guinea pigs. Both short-term (4 weeks) and long-term (12 weeks) effects of the drug were observed. The drug administration resulted in a marked decrease in sperm density, sperm motility and cellular energy content (ATP). Zona pellucida penetration by the sperm obtained from drug-treated animals was significantly lower when compared with sperm from normal animals. Histopathological findings exhibited partial arrest of spermatogenesis. Partial to complete recovery was observed after 4 and 6 weeks of withdrawal of the drug treatment.
维拉帕米，一种钙通道阻滞剂，以三种不同剂量口服给予豚鼠。观察了该药物的短期（4周）和长期（12周）效应。给药导致精子密度、精子活力和细胞能量含量（ATP）显著降低。与正常动物的精子相比，从药物处理动物获得的精子穿透透明带的能力明显较低。组织病理学结果显示精子发生部分停滞。在停药4周和6周后观察到部分至完全恢复。
