Mo Peiting, Zhao Ziran, Ke Xinpeng, Fan Yong, Li Chaohui
Key Laboratory for Major Obstetric Diseases of Guangdong Province, Department of Obstetrics and Gynecology, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Front Cell Dev Biol. 2023 Sep 18;11:1258574. doi: 10.3389/fcell.2023.1258574. eCollection 2023.
An increasing number of men require long-term drug therapy for various diseases. However, the effects of long-term drug therapy on male fertility are often not well evaluated in clinical practice. Meanwhile, the development of stem cell therapy and exosomes treatment methods may provide a new sight on treating male infertility. This article reviews the influence and mechanism of small molecule medications on male fertility, as well as progress of stem cell and exosomes therapy for male infertility with the purpose on providing suggestions (recommendations) for evaluating the effect of drugs on male fertility (both positive and negative effect on male fertility) in clinical application and providing strategies for diagnosis and treatment of male infertility.
越来越多的男性因各种疾病需要长期药物治疗。然而，在临床实践中，长期药物治疗对男性生育能力的影响往往没有得到充分评估。与此同时，干细胞疗法和外泌体治疗方法的发展可能为治疗男性不育症提供新的视角。本文综述了小分子药物对男性生育能力的影响及机制，以及干细胞和外泌体治疗男性不育症的研究进展，旨在为临床应用中评估药物对男性生育能力的影响（包括对男性生育能力的正面和负面影响）提供建议，并为男性不育症的诊断和治疗提供策略。
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