一只怀孕恒河猴（猕猴属）感染产单核细胞李斯特菌所致的脑膜脑炎
Meningoencephalitis due to Listeria monocytogenes in a pregnant rhesus macaque (Macaca mulatta).
作者信息
Lemoy Marie-Josee M F, Lopes Danielle A, Reader J Rachel, Westworth Diccon R, Tarara Ross P
机构信息
Department of Primate Medicine, California National Primate Center, University of California, Davis, California, USA.
出版信息
Comp Med. 2012 Oct;62(5):443-7.
We here report a spontaneous case of meningoencephalitis due to Listeria monocytogenes in an adult primiparous rhesus macaque (Macaca mulatta) during an outbreak of listeriosis in an outdoor enclosure. Clinical signs included tremors, abnormal posture, and altered mental status. Hematology and analyses of cerebrospinal fluid were consistent with bacterial infection. Pure cultures of L. monocytogenes were recovered from the placenta-abortus, cerebrospinal fluid, and brain tissue. The macaque did not respond to treatment and was euthanized. Histopathologic examination of the brain revealed acute meningoencephalitis. This case represents an unusual clinical and pathologic presentation of listeriosis in a nonhuman primate in which the dam and fetus both were affected.
我们在此报告一例成年初产恒河猴（猕猴属）因产单核细胞李斯特菌导致的脑膜脑炎自发病例，该病例发生在户外围栏内的李斯特菌病暴发期间。临床症状包括震颤、异常姿势和精神状态改变。血液学检查和脑脊液分析结果与细菌感染相符。从胎盘-流产物、脑脊液和脑组织中分离出了产单核细胞李斯特菌的纯培养物。这只猕猴对治疗无反应，最终实施了安乐死。脑部组织病理学检查显示为急性脑膜脑炎。该病例代表了非人灵长类动物李斯特菌病一种不寻常的临床和病理表现，其中母猴和胎儿均受到影响。
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