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人类和反刍动物中由单核细胞增生李斯特菌引起的菱形脑炎:一种日益增多的人畜共患病?

Rhombencephalitis Caused by Listeria monocytogenes in Humans and Ruminants: A Zoonosis on the Rise?

作者信息

Oevermann Anna, Zurbriggen Andreas, Vandevelde Marc

机构信息

Neurocenter, Department of Clinical Research and Veterinary Public Health, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.

出版信息

Interdiscip Perspect Infect Dis. 2010;2010:632513. doi: 10.1155/2010/632513. Epub 2010 Feb 28.

DOI:10.1155/2010/632513
PMID:20204066
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2829626/
Abstract

Listeriosis is an emerging zoonotic infection of humans and ruminants worldwide caused by Listeria monocytogenes (LM). In both host species, CNS disease accounts for the high mortality associated with listeriosis and includes rhombencephalitis, whose neuropathology is strikingly similar in humans and ruminants. This review discusses the current knowledge about listeric encephalitis, and involved host and bacterial factors. There is an urgent need to study the molecular mechanisms of neuropathogenesis, which are poorly understood. Such studies will provide a basis for the development of new therapeutic strategies that aim to prevent LM from invading the brain and spread within the CNS.

摘要

李斯特菌病是一种在全球范围内出现的人畜共患感染病,由单核细胞增生李斯特菌(LM)引起,感染对象包括人类和反刍动物。在这两种宿主物种中,中枢神经系统疾病导致了与李斯特菌病相关的高死亡率,其中包括菱形脑炎,其神经病理学在人类和反刍动物中极为相似。本综述讨论了关于李斯特菌性脑炎以及相关宿主和细菌因素的现有知识。迫切需要研究神经发病机制的分子机制,目前对此了解甚少。此类研究将为开发新的治疗策略提供基础,这些策略旨在防止LM侵入大脑并在中枢神经系统内扩散。

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Exogenous Sources of Listeria Contamination in Raw Ewe's Milk.生羊奶中李斯特菌污染的外源来源。
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Virulence Heterogeneity of Listeria monocytogenes Strains From Various Sources (Food, Human, Animal) in Immunocompetent Mice and its Association With Typing Characteristics.不同来源(食品、人类、动物)的单核细胞增生李斯特菌菌株在免疫功能正常小鼠中的毒力异质性及其与分型特征的关联
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Novel primers drive accurate SYBR Green PCR detection of Listeria monocytogenes and Listeria innocua in cultures and mushrooms.新型引物可实现对培养物和蘑菇中单核细胞增生李斯特菌和无害李斯特菌的准确SYBR Green PCR检测。
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