Austrian Agency for Health and Food Safety (AGES), Binational Austrian-German Listeria Reference Centre, Spargelfeldstrasse 191, Vienna, Austria.
Clin Microbiol Infect. 2010 Jan;16(1):16-23. doi: 10.1111/j.1469-0691.2009.03109.x.
Listeria monocytogenes is the causative agent of human listeriosis, a potentially fatal foodborne infection. Clinical manifestations range from febrile gastroenteritis to more severe invasive forms, including sepsis, meningitis, rhombencephalitis, perinatal infections, and abortions. In recent years, an increasing rate of listeriosis has been reported in several European countries. These increases primarily reflect a higher rate of bacteraemic listeriosis in those > or =65 years of age, and are not otherwise correlated with geography, gender, ethnicity, socioeconomic factors or infectious serotypes. In the late 1980s, an upsurge in listeriosis rates was due to the contamination of a small number of food products. However, a restricted range of strains was responsible for most of the additional cases at that time, and no evidence exists for such a pattern since 2001. From a clinical perspective, the importance of isolating the pathogen as a prerequisite for an accurate epidemiological investigation and ultimately stopping transmission cannot be overemphasized.
单核细胞增生李斯特菌是人类李斯特菌病的病原体，是一种潜在致命的食源性感染。临床表现从发热性胃肠炎到更严重的侵袭性形式不等，包括败血症、脑膜炎、脑脊髓炎、围产期感染和流产。近年来，几个欧洲国家李斯特菌病的发病率不断上升。这些增加主要反映了年龄≥65 岁人群中菌血症性李斯特菌病的发生率更高，与地理位置、性别、种族、社会经济因素或感染血清型无关。在 20 世纪 80 年代末，由于少数食品受到污染，李斯特菌病的发病率急剧上升。然而，当时大多数额外病例是由少数菌株引起的，自 2001 年以来，没有证据表明存在这种模式。从临床角度来看，作为准确流行病学调查和最终阻断传播的前提，分离病原体的重要性怎么强调都不为过。
