Guttman Orlee R, Zachos Mary
Division of Gastroenterology, Hepatology and Nutrition, British Columbia Children's Hospital, Vancouver, British Columbia;
Paediatr Child Health. 2011 Nov;16(9):554-6. doi: 10.1093/pch/16.9.554.
Drug-induced esophageal injury is an under-recognized clinical problem, and is associated with antibiotic use in more than 50% of cases. The current report describes a teenage girl who presented with symptoms of pill-induced esophagitis following doxycycline use. Subsequent investigations identified a previously undiagnosed vascular ring. Although most patients who experience drug-induced esophageal injury have no underlying anatomical or functional disorder of the esophagus, the condition is more common in areas of esophageal narrowing. The present case illustrates the possibility of an occult esophageal obstruction representing a risk factor for pill esophagitis. The etiologies, mechanisms and management of drug-induced esophageal injury are reviewed, and aspects of vascular rings that are relevant to paediatricians are discussed.
药物性食管损伤是一个未得到充分认识的临床问题，超过50%的病例与使用抗生素有关。本报告描述了一名少女，在使用强力霉素后出现药丸性食管炎症状。随后的检查发现了一个先前未被诊断出的血管环。尽管大多数经历药物性食管损伤的患者没有潜在的食管解剖或功能紊乱，但这种情况在食管狭窄区域更为常见。本病例说明了隐匿性食管梗阻可能是药丸性食管炎的一个危险因素。本文回顾了药物性食管损伤的病因、机制及处理，并讨论了与儿科医生相关的血管环问题。
