Chung Sang-Bong, Suh Yeon-Lim, Lee Jung-Il
Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
J Korean Neurosurg Soc. 2012 Sep;52(3):250-3. doi: 10.3340/jkns.2012.52.3.250. Epub 2012 Sep 30.
We report a rare case of cerebellar liponeurocytoma with an unusually aggressive histopathology. A 49-year-old man presented with a four-month history of headache, vertigo, and progressive swaying gait. Magnetic resonance imaging showed a 3×3.5 cm sized relatively well-demarcated round mass lesion in the fourth ventricle, characterized by high signal intensity on T2-weighted images. Postcontrast images revealed strong enhancement of the solid portion and the cyst wall. The patient underwent suboccipital craniectomy and tumor removal. The pathologic diagnosis was cerebellar liponeurocytoma. Adjuvant radiotherapy was offered due to concerns related to the high proliferative index (Ki-67, 13.68%) of the tumor. At the last routine postoperative follow-up visit (12 months), the patient complained of no specific symptom and there was no evidence of tumor recurrence. However, long-term follow-up and the analysis of similar cases are necessary because of the low number of reports and the short follow-up of cases.
我们报告一例罕见的具有异常侵袭性组织病理学特征的小脑脂肪神经细胞瘤。一名49岁男性，有4个月的头痛、眩晕和进行性摇摆步态病史。磁共振成像显示第四脑室内有一个大小为3×3.5 cm、边界相对清晰的圆形肿块，在T2加权图像上呈高信号强度。增强扫描图像显示实性部分和囊肿壁明显强化。患者接受了枕下开颅肿瘤切除术。病理诊断为小脑脂肪神经细胞瘤。由于担心肿瘤的高增殖指数（Ki-67，13.68%），给予了辅助放疗。在术后最后一次常规随访（12个月）时，患者无特殊症状，也没有肿瘤复发的证据。然而，由于报告数量少且病例随访时间短，有必要进行长期随访并分析类似病例。
