Carlisle E J, Allen J D, Kernohan W G, Anderson J, Adgey A A
Regional Medical Cardiology Centre, Royal Victoria Hospital, Belfast, N. Ireland.
Eur Heart J. 1990 Feb;11(2):173-81. doi: 10.1093/oxfordjournals.eurheartj.a059674.
Fast Fourier Transform analysis was used to study ventricular fibrillation induced by several different methods in 43 greyhounds anaesthetized with sodium pentobarbitone. The dominant frequency at the body surface of ventricular fibrillation induced electrically in non-ischaemic hearts was initially 9.9 +/- 0.7 Hz, remained above 9 Hz for 70 s and then rapidly fell to 5 Hz. The dominant frequency of ventricular fibrillation induced by acute occlusion (initially 12.3 +/- 0.2 Hz), or by reperfusion (12.2 +/- 0.4 Hz) of the anterior descending branch of the left coronary artery, showed a similar time-course. However, ventricular fibrillation induced by administration of potassium (4.8 +/- 0.8 Hz) or ouabain (7.1 +/- 1.1 Hz) was significantly slower. Fibrillation recorded from the endocardium of the heart initially showed a similar dominant frequency to that recorded at the body surface, but there was no significant fall in frequency over 3.3 mins. There was little difference in the time-course of fibrillation in the non-ischaemic heart recorded directly from the epicardium or from a surface lead. These findings may be of relevance to the poor response to DC countershock after prolonged ventricular fibrillation, hyperkalaemia or cardiac glycosides.
采用快速傅里叶变换分析方法，对43只用戊巴比妥钠麻醉的灵缇犬，通过几种不同方法诱发心室颤动进行了研究。在非缺血性心脏中，电诱发心室颤动时体表的主导频率最初为9.9±0.7Hz，在70秒内保持在9Hz以上，然后迅速降至5Hz。左冠状动脉前降支急性闭塞（最初为12.3±0.2Hz）或再灌注（12.2±0.4Hz）诱发心室颤动的主导频率呈现相似的时间进程。然而，钾（4.8±0.8Hz）或哇巴因（7.1±1.1Hz）诱发的心室颤动明显较慢。从心脏心内膜记录的颤动最初显示出与体表记录相似的主导频率，但在3.3分钟内频率没有明显下降。直接从心外膜或表面导联记录的非缺血性心脏颤动的时间进程几乎没有差异。这些发现可能与长时间心室颤动、高钾血症或强心苷后直流电除颤反应不佳有关。
