Tashiro N, Kumagai K, Yamanouchi Y, Matsuo K, Hiroki T, Arakawa K
Department of Internal Medicine, Fukuoka University, School of Medicine, Japan.
Clin Cardiol. 1992 Oct;15(10):733-8. doi: 10.1002/clc.4960151032.
To investigate the effect of dibutyryl cyclic AMP (dbcAMP) on ventricular fibrillation after coronary reperfusion, the proximal portion of the anterior descending branch of left coronary artery was reperfused 20 min after ligation in 24 cats. McFee X Y Z electrocardiograms were recorded and ventricular fibrillation was analyzed using a fast Fourier transform analysis (FFT). Ventricular fibrillation occurred in 20 of 24 cases. Sixty seconds after the occurrence of ventricular fibrillation, an intracardiac infusion of dbcAMP was administered. Nine of the 20 were defibrillated and converted to sinus rhythm or junctional rhythm after the administration of dbcAMP. The amplitude and frequency of the main power spectrum of the ventricular fibrillation waves were analyzed by FFT before and after the infusion of saline or dbcAMP. In the saline group there was no significant change in FFT. However, in the dbcAMP group, the amplitude increased significantly from 0.036 +/- 0.015 (MV--2) to 0.054 +/- 0.013 (MV--2) (p < 0.01) and the frequency decreased significantly from 4.22 +/- 1.37 (Hz) to 1.33 +/- 0.91 (Hz) (p < 0.01). Those results indicate that dbcAMP increased the amplitude and decreased the frequency of the main power spectrum of ventricular fibrillation analyzed by FFT. These distinctive changes in FFT analysis were associated with defibrillation in 9 of 20 cases.
为研究二丁酰环磷腺苷（dbcAMP）对冠状动脉再灌注后室颤的影响，对24只猫在结扎左冠状动脉前降支近端20分钟后进行再灌注。记录McFee X Y Z心电图，并使用快速傅里叶变换分析（FFT）分析室颤情况。24例中有20例发生室颤。室颤发生60秒后，进行心内注射dbcAMP。20例中的9例在注射dbcAMP后除颤并转为窦性心律或交界性心律。在注射生理盐水或dbcAMP前后，通过FFT分析室颤波主峰功率谱的幅度和频率。在生理盐水组，FFT无显著变化。然而，在dbcAMP组，幅度从0.036±0.015（MV-2）显著增加至0.054±0.013（MV-2）（p<0.01），频率从4.22±1.37（Hz）显著降低至1.33±0.91（Hz）（p<0.01）。这些结果表明，dbcAMP增加了通过FFT分析的室颤主峰功率谱的幅度并降低了频率。FFT分析中的这些显著变化与20例中的9例除颤有关。
