Zou Li-wei, Xu Xiao-juan, Liu Ting, Wang Han-yong, Fan Wen-jing, Wang Xing-hua, Zhang Zhao-xiang, Zhai Jin-xia
Department of Occupational and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui Province, China.
Genet Test Mol Biomarkers. 2013 Jan;17(1):78-84. doi: 10.1089/gtmb.2012.0216. Epub 2012 Nov 1.
Results from published studies on the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and prostate cancer (PCa) risk are inconsistent. To derive a more precise estimate, we performed a meta-analysis.
We searched in the PubMed and Elsevier Science Direct database for studies on the association between the COMT Val158Met polymorphism and PCa. We used the odds ratio with 95% confidence interval for PCa risk, detected potential sources of heterogeneity with the Chi-square-based Q-test, performed sensitivity analysis of studies adapted to the Hardy-Weinberg equilibrium.
We found seven case-control studies included 2292 patients and 2158 controls. Fix-effects meta-analysis failed to explore any significant association of PCa with the genetic model and the allelic model of COMT Val158Met. We also did not detect any association in the subgroup analysis by ethnicity in all genetic models. The gene-based analysis suggested that the genetic polymorphism in COMT is not associated with PCa.
There is no association between the COMT Val158Met polymorphism and PCa.
已发表的关于儿茶酚-O-甲基转移酶（COMT）Val158Met基因多态性与前列腺癌（PCa）风险之间关联的研究结果并不一致。为了得出更精确的估计值，我们进行了一项荟萃分析。
我们在PubMed和爱思唯尔科学Direct数据库中检索了关于COMT Val158Met基因多态性与PCa之间关联的研究。我们使用优势比及95%置信区间来评估PCa风险，通过基于卡方的Q检验检测潜在的异质性来源，并对符合哈迪-温伯格平衡的研究进行敏感性分析。
我们发现七项病例对照研究，共纳入2292例患者和2158例对照。固定效应荟萃分析未能发现PCa与COMT Val158Met的遗传模型和等位基因模型之间存在任何显著关联。在所有遗传模型中，按种族亚组分析中，我们也未检测到任何关联。基于基因的分析表明，COMT基因多态性与PCa无关。
COMT Val158Met基因多态性与PCa之间不存在关联。
