儿茶酚-O-甲基转移酶Val158Met（158G/A）多态性与自杀易感性的关联：一项荟萃分析。
Association between Catechol-O-Methyltransferase Val158Met (158G/A) Polymorphism and Suicide Susceptibility: A Meta-analysis.
作者信息
Sadeghiyeh Tahereh, Hosseini Biouki Fatemeh, Mazaheri Mahta, Zare-Shehneh Masoud, Neamatzadeh Hossein, Poursharif Zahra
机构信息
Department of Psychology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
出版信息
J Res Health Sci. 2017 Jun 24;17(2):e00383.
BACKGROUND
Common functional Val158Met polymorphism in the Catechol-O-methyltransferase (COMT) gene may have an impact on an individual's susceptibility to suicide, but individually published results are inconclusive. Therefore, we performed this meta-analysis to provide a more precise estimation of the association between COMT 158G/A (COMT Val158Met) polymorphism and suicide susceptibility.
STUDY DESIGN
A cross-sectional study.
METHODS
This systematic review and meta-analysis is a comprehensive literature search of PubMed, Scopus, Web of Science and Google Scholar databases was conducted on case-control studies published up to Mar 2017. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.
RESULTS
We identified 14 eligible case-control studies, including 2353 suicide attempters and 2593 controls. The pooled results indicated that COMT 158G/A (COMT Val158Met) polymorphism was not significantly associated with increased overall suicide risk. The same results were revealed based on ethnicity, Hardy-Weinberg equilibrium (HWE) status and genotyping technique. However, there was significant association between COMT Val158Met polymorphism and suicide risk among females under the homozygote (AA vs. GG: OR=1.829, 95% CI=1.158-2.889, P=0.010) and recessive (AA vs. AG +GG: OR = 1.787, 95% CI=1.195, 2.671, P=0.005) models, but not among males.
CONCLUSIONS
COMT 158G/A (COMT Val158Met) polymorphism was associated with suicide susceptibility only in females.
背景
儿茶酚-O-甲基转移酶（COMT）基因中常见的功能性缬氨酸158蛋氨酸多态性可能会影响个体的自杀易感性，但单独发表的结果尚无定论。因此，我们进行了这项荟萃分析，以更精确地估计COMT 158G/A（COMT Val158Met）多态性与自杀易感性之间的关联。
研究设计
横断面研究。
方法
本系统评价和荟萃分析对截至2017年3月发表的病例对照研究进行了全面的文献检索，检索了PubMed、Scopus、Web of Science和谷歌学术数据库。计算了粗比值比（OR）及其95%置信区间（CI）。
结果
我们确定了14项符合条件的病例对照研究，包括2353名自杀未遂者和2593名对照。汇总结果表明，COMT 158G/A（COMT Val158Met）多态性与总体自杀风险增加无显著关联。基于种族、哈迪-温伯格平衡（HWE）状态和基因分型技术得出了相同的结果。然而，在纯合子（AA与GG：OR=1.829，95%CI=1.158-2.889，P=0.010）和隐性（AA与AG+GG：OR=1.787，95%CI=1.195，2.671，P=0.005）模型下，COMT Val158Met多态性与女性自杀风险之间存在显著关联，但男性中不存在。
结论
COMT 158G/A（COMT Val158Met）多态性仅与女性的自杀易感性有关。
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